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- W2048890750 abstract "T HE eczema that occurs in t.he breast-fed infant presents one of the most baffling problems which the physician encounters. The secretion of certain drugs by the breast and the earlier belief that immune bodies were passed through colostrum, have led to t,he supposition that (allergic) antigens might likewise be secreted in the breast milk. Clinically, this appears subst,antiated by numerous reports. Experimentally, Shannon1 claimed to have obt,ained evidence of egg white in breast milk, since the latter on injection of guinea pigs sensitized to egg white, produced an anaphylactic response. Stuart,” however, in a more exhaustive study, was unable to confirm Shannon’s work. That the antigens may be absorbed unaltered from the intest,inal tract has been demonstrated by Mcl~loss and Worthen,” who followed precipitin response after oral ingest,ion. There is, however, some discrepancy between precipitin (anaphylactic ant,ibody) and the substance responsible for the skin t,est of allergy (reagin). There is also the difficulty in drawing conclusions referable to human allergy from experimental animal anaphylaxis. Walzer,4 Gay and Chant.5 and others have, however, demonstrated t,he enteral absorption of allergic antigen by a simple modification of the Prausnitz-Kiistner technic. Since this offers a closer parallel with human allergic phenomena, the following experiments were devised to test by this method the secretion of ant.igens in the breast milk." @default.
- W2048890750 created "2016-06-24" @default.
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- W2048890750 date "1931-05-01" @default.
- W2048890750 modified "2023-09-24" @default.
- W2048890750 title "Enteral absorption of the antigen and the apparent failure of antigen secretion in human milk" @default.
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- W2048890750 doi "https://doi.org/10.1016/s0021-8707(31)90075-0" @default.
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