FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048893350> ?p ?o ?g. }

• W2048893350 endingPage "139" @default.
• W2048893350 startingPage "124" @default.
• W2048893350 abstract "Abstract Concentrations of urea, ammonium, sodium and potassium as well as water content were measured in the renal papilla, medulla and cortex, the heart muscle, plasma and urine of rats, in the dehydrated state, the non-diuretic state and after 3 or 8 hr of sustained brisk water diuresis. The same measurements were made on rats which had received a natriuretic dose of hydrochlorothiazide during the 8th hr of water diuresis. Water content of renal tissue increased from cortex to inner medulla in all conditions. In hydrated rats the water content of all layers of renal tissue increased during the first 3 hr and remained stable thereafter. “Exaltation” of urea excretion continued during the first 2 hr of water diuresis, but subsided subsequently. Urinary urea concentrations were equal to, or higher than, urea concentrations in papillary water in the dehydrated and in the non-diuretic states. After 3 hr of water diuresis, urea concentrations decreased in all layers of renal tissue. The papillary urea concentration remained consistently higher than the urinary concentration. The papillo-urinary urea gradient of approximately 80 mmol/1 decreased to 19 mmol/1 after 8 hr of water diuresis, and disappeared in continuous water diuresis sustained over 30 days. These data are interpreted as a consequence of sequestration or tissue binding of urea in compartments of different accessibility to water flowing through papillary and medullary tissues. Cortical tissue water contained more urea than plasma, under all conditions investigated. A part of cortical urea may be sequestered in particular compartments. The cortico-papillary sodium concentration profile corresponded to a 2.8–5.1 fold concentration ratio for sodium in the non-diuretic and in the dehydrated states and decreased during 8 hr of water diuresis. The urinary sodium concentration consistently remained much lower than renal or plasma concentrations. The low sodium concentration in cortical tissue water allows an upper limit of approximately 1 2 to be set for the contribution of intratubular fluid to total tissue water. Potassium concentration in papillary tissue water was equal to or lower than cortical potassium concentration and did not change significantly in water diuresis. Calculated urinary osmolalities were higher than measured values in concentrated urine and in plasma, but were equal in dilute urine. The osmolar concentration profiles in renal tissue depended more on urea than on salt concentrations. Urinary ammonium concentration was higher than the papillary concentration in the dehydrated and the non-diuretic state, but lower in water diuresis. Hydrochlorothiazide, in water diuresis, caused a considerable increase in the urinary sodium concentration and excretion, and a slight increase in the urinary potassium excretion, but did not increase urine flow. Hydrochlorothiazide did not cause a significant decrease in the renal clearance of urea under these circumstances, but induced a slight depression of papillary urea concentration." @default.
• W2048893350 created "2016-06-24" @default.
• W2048893350 creator A5007653471 @default.
• W2048893350 creator A5060871060 @default.
• W2048893350 date "1967-03-01" @default.
• W2048893350 modified "2023-09-25" @default.
• W2048893350 title "Intrarenal urea and electrolyte concentrations as influenced by water diuresis and by hydrochlorothiazide" @default.
• W2048893350 cites W1871665033 @default.
• W2048893350 cites W1979655472 @default.
• W2048893350 cites W2009450572 @default.
• W2048893350 cites W2017002925 @default.
• W2048893350 cites W2041696052 @default.
• W2048893350 cites W2049741850 @default.
• W2048893350 cites W2051142023 @default.
• W2048893350 cites W2062351818 @default.
• W2048893350 cites W2082476745 @default.
• W2048893350 cites W2084214083 @default.
• W2048893350 cites W2113994340 @default.
• W2048893350 cites W2147329419 @default.
• W2048893350 cites W2166397396 @default.
• W2048893350 cites W2258090097 @default.
• W2048893350 cites W2262395996 @default.
• W2048893350 cites W2268423235 @default.
• W2048893350 cites W2272806742 @default.
• W2048893350 cites W2278151402 @default.
• W2048893350 cites W2278221945 @default.
• W2048893350 cites W2341051902 @default.
• W2048893350 cites W2405064427 @default.
• W2048893350 cites W2409824424 @default.
• W2048893350 cites W2415607020 @default.
• W2048893350 cites W2415942952 @default.
• W2048893350 cites W2417140924 @default.
• W2048893350 cites W2417796350 @default.
• W2048893350 cites W2460820387 @default.
• W2048893350 cites W2465850646 @default.
• W2048893350 cites W2597249424 @default.
• W2048893350 cites W2605199653 @default.
• W2048893350 doi "https://doi.org/10.1016/0014-2999(67)90049-0" @default.
• W2048893350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6060191" @default.
• W2048893350 hasPublicationYear "1967" @default.
• W2048893350 type Work @default.
• W2048893350 sameAs 2048893350 @default.
• W2048893350 citedByCount "21" @default.
• W2048893350 countsByYear W20488933502014 @default.
• W2048893350 crossrefType "journal-article" @default.
• W2048893350 hasAuthorship W2048893350A5007653471 @default.
• W2048893350 hasAuthorship W2048893350A5060871060 @default.
• W2048893350 hasConcept C126322002 @default.
• W2048893350 hasConcept C134018914 @default.
• W2048893350 hasConcept C147789679 @default.
• W2048893350 hasConcept C159641895 @default.
• W2048893350 hasConcept C17525397 @default.
• W2048893350 hasConcept C185592680 @default.
• W2048893350 hasConcept C2779547328 @default.
• W2048893350 hasConcept C2780361556 @default.
• W2048893350 hasConcept C2780365088 @default.
• W2048893350 hasConcept C55493867 @default.
• W2048893350 hasConcept C68801617 @default.
• W2048893350 hasConcept C71924100 @default.
• W2048893350 hasConcept C84393581 @default.
• W2048893350 hasConceptScore W2048893350C126322002 @default.
• W2048893350 hasConceptScore W2048893350C134018914 @default.
• W2048893350 hasConceptScore W2048893350C147789679 @default.
• W2048893350 hasConceptScore W2048893350C159641895 @default.
• W2048893350 hasConceptScore W2048893350C17525397 @default.
• W2048893350 hasConceptScore W2048893350C185592680 @default.
• W2048893350 hasConceptScore W2048893350C2779547328 @default.
• W2048893350 hasConceptScore W2048893350C2780361556 @default.
• W2048893350 hasConceptScore W2048893350C2780365088 @default.
• W2048893350 hasConceptScore W2048893350C55493867 @default.
• W2048893350 hasConceptScore W2048893350C68801617 @default.
• W2048893350 hasConceptScore W2048893350C71924100 @default.
• W2048893350 hasConceptScore W2048893350C84393581 @default.
• W2048893350 hasIssue "2" @default.
• W2048893350 hasLocation W20488933501 @default.
• W2048893350 hasLocation W20488933502 @default.
• W2048893350 hasOpenAccess W2048893350 @default.
• W2048893350 hasPrimaryLocation W20488933501 @default.
• W2048893350 hasRelatedWork W1966119954 @default.
• W2048893350 hasRelatedWork W1993617885 @default.
• W2048893350 hasRelatedWork W2036863687 @default.
• W2048893350 hasRelatedWork W2050825966 @default.
• W2048893350 hasRelatedWork W2092185218 @default.
• W2048893350 hasRelatedWork W2120489977 @default.
• W2048893350 hasRelatedWork W2221398608 @default.
• W2048893350 hasRelatedWork W2414960153 @default.
• W2048893350 hasRelatedWork W3163121588 @default.
• W2048893350 hasRelatedWork W4251040403 @default.
• W2048893350 hasVolume "1" @default.
• W2048893350 isParatext "false" @default.
• W2048893350 isRetracted "false" @default.
• W2048893350 magId "2048893350" @default.
• W2048893350 workType "article" @default.