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- W2048893497 abstract "Anti-histone antibodies are currently detected by micro ELISA in systemic lupus erythematosus sera from humans, mice and dogs. Here we show that the control-heated sera may bind non-specifically to the whole histones and histone fractions. The heated immunoglobulins binding to histones are mainly IgG and to a lesser extent IgA, but never IgM. These false positive ELISA reactions occurred only with aggregated IgG which binds to histones via Fc; IgM rheumatoid factor prevented their fixation. Immune complexes do not seem to interfere significantly in the detection of anti-histone antibodies with the ELISA test." @default.
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- W2048893497 date "1984-11-30" @default.
- W2048893497 modified "2023-09-25" @default.
- W2048893497 title "Non-specific binding of heat-aggregated IgG to histone detected by ELISA." @default.
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- W2048893497 doi "https://doi.org/10.1016/0022-1759(84)90295-3" @default.
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