FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048896540> ?p ?o ?g. }

• W2048896540 abstract "DNA double-strand breaks (DSBs) are repaired by two major pathways: homologous recombination (HR) and non-homologous end-joining (NHEJ). The choice between HR and NHEJ is highly regulated during the cell cycle. DNA-end resection, an evolutionarily conserved process that generates long stretches of single-stranded DNA, plays a critical role in pathway choice, as it commits cells to HR, while, at the same time, suppressing NHEJ. As erroneous DSB repair is a major source of genomic instability-driven tumorigenesis, DNA-end resection factors, and in particular their regulation by post-translational modifications, have become the subject of extensive research over the past few years. Recent work has implicated phosphorylation at S/T-P motifs by cyclin-dependent kinases (CDKs) as a major regulatory mechanism of DSB repair. Intriguingly, CDK activity was found to be critically important for the coordinated and timely execution of DNA-end resection, and key players in this process were subsequently identified as CDK substrates. In this mini review, we provide an overview of the current understanding of how the DNA-end resection machinery in yeast and human cells is controlled by CDK-mediated phosphorylation." @default.
• W2048896540 created "2016-06-24" @default.
• W2048896540 creator A5065201058 @default.
• W2048896540 creator A5067493337 @default.
• W2048896540 creator A5068745105 @default.
• W2048896540 date "2013-01-01" @default.
• W2048896540 modified "2023-10-02" @default.
• W2048896540 title "Controlling DNA-end resection: a new task for CDKs" @default.
• W2048896540 cites W1585519565 @default.
• W2048896540 cites W1752089945 @default.
• W2048896540 cites W1851483641 @default.
• W2048896540 cites W1875580551 @default.
• W2048896540 cites W1943931237 @default.
• W2048896540 cites W1967667819 @default.
• W2048896540 cites W1969129513 @default.
• W2048896540 cites W1969503475 @default.
• W2048896540 cites W1970038285 @default.
• W2048896540 cites W1970445060 @default.
• W2048896540 cites W1974082653 @default.
• W2048896540 cites W1974706661 @default.
• W2048896540 cites W1978054036 @default.
• W2048896540 cites W1979385111 @default.
• W2048896540 cites W1980005922 @default.
• W2048896540 cites W1980246358 @default.
• W2048896540 cites W1981816841 @default.
• W2048896540 cites W1989136612 @default.
• W2048896540 cites W1990441769 @default.
• W2048896540 cites W1991619611 @default.
• W2048896540 cites W1991917259 @default.
• W2048896540 cites W1993026474 @default.
• W2048896540 cites W1998163656 @default.
• W2048896540 cites W2003847336 @default.
• W2048896540 cites W2009661890 @default.
• W2048896540 cites W2010521897 @default.
• W2048896540 cites W2011902133 @default.
• W2048896540 cites W2012882202 @default.
• W2048896540 cites W2014946189 @default.
• W2048896540 cites W2019394964 @default.
• W2048896540 cites W2019396216 @default.
• W2048896540 cites W2021870890 @default.
• W2048896540 cites W2023766708 @default.
• W2048896540 cites W2027928541 @default.
• W2048896540 cites W2029791035 @default.
• W2048896540 cites W2033651349 @default.
• W2048896540 cites W2034949406 @default.
• W2048896540 cites W2037004712 @default.
• W2048896540 cites W2037095827 @default.
• W2048896540 cites W2039839254 @default.
• W2048896540 cites W2043895957 @default.
• W2048896540 cites W2045090937 @default.
• W2048896540 cites W2048839078 @default.
• W2048896540 cites W2050987046 @default.
• W2048896540 cites W2051066694 @default.
• W2048896540 cites W2052547134 @default.
• W2048896540 cites W2052981964 @default.
• W2048896540 cites W2054914405 @default.
• W2048896540 cites W2056527762 @default.
• W2048896540 cites W2059977521 @default.
• W2048896540 cites W2062284662 @default.
• W2048896540 cites W2068972095 @default.
• W2048896540 cites W2072668354 @default.
• W2048896540 cites W2072806146 @default.
• W2048896540 cites W2075152619 @default.
• W2048896540 cites W2083431317 @default.
• W2048896540 cites W2083731894 @default.
• W2048896540 cites W2083740738 @default.
• W2048896540 cites W2092462528 @default.
• W2048896540 cites W2094020226 @default.
• W2048896540 cites W2096770011 @default.
• W2048896540 cites W2100929591 @default.
• W2048896540 cites W2104128454 @default.
• W2048896540 cites W2107991933 @default.
• W2048896540 cites W2109125373 @default.
• W2048896540 cites W2109879947 @default.
• W2048896540 cites W2117602431 @default.
• W2048896540 cites W2119628884 @default.
• W2048896540 cites W2122543263 @default.
• W2048896540 cites W2123929534 @default.
• W2048896540 cites W2126404651 @default.
• W2048896540 cites W2127392515 @default.
• W2048896540 cites W2129069151 @default.
• W2048896540 cites W2129777487 @default.
• W2048896540 cites W2131978108 @default.
• W2048896540 cites W2132794930 @default.
• W2048896540 cites W2140638448 @default.
• W2048896540 cites W2141575449 @default.
• W2048896540 cites W2142335883 @default.
• W2048896540 cites W2145200068 @default.
• W2048896540 cites W2145506563 @default.
• W2048896540 cites W2146204567 @default.
• W2048896540 cites W2147054306 @default.
• W2048896540 cites W2153451248 @default.
• W2048896540 cites W2153856808 @default.
• W2048896540 cites W2157798305 @default.
• W2048896540 cites W2157899948 @default.
• W2048896540 cites W2158546639 @default.
• W2048896540 cites W2158602985 @default.
• W2048896540 cites W2160212229 @default.
• W2048896540 cites W2161608278 @default.
• W2048896540 cites W2163377650 @default.

• next