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- W2048899247 abstract "Maintenance of the chromatin states and histone modification patterns during transcription is essential for proper gene regulation and cell survival. Histone octamer survives moderate transcription, but is evicted during intense transcription in vivo by RNA polymerase II (Pol II). Previously we have shown that nucleosomes can survive transcription by single Pol II complexes in vitro. To study the mechanism of histone displacement from DNA, the encounter between multiple complexes of RNA polymerase and a nucleosome was analyzed in vitro. Multiple transcribing Pol II complexes can efficiently overcome the high nucleosomal barrier and displace the entire histone octamer, matching the observations in vivo. DNA-bound histone hexamer left behind the first complex of transcribing enzyme is evicted by the next Pol II complex. Thus transcription by single Pol II complexes allows survival of the original H3/H4 histones, while multiple, closely spaced complexes of transcribing Pol II can induce displacement of all core histones along the gene." @default.
- W2048899247 created "2016-06-24" @default.
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- W2048899247 date "2010-06-07" @default.
- W2048899247 modified "2023-10-09" @default.
- W2048899247 title "RNA polymerase complexes cooperate to relieve the nucleosomal barrier and evict histones" @default.
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- W2048899247 doi "https://doi.org/10.1073/pnas.1001148107" @default.
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