FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048919163> ?p ?o ?g. }

• W2048919163 endingPage "264" @default.
• W2048919163 startingPage "258" @default.
• W2048919163 abstract "The multiple myelin basic protein (MBP) isoforms expressed by myelinating cells are now known to have different expression patterns. The relative abundance of the isoforms containing exon II is greater early in myelinogenesis, whereas in compact myelin the isoforms lacking this exon are more abundant. Further, the individual MBPs exhibit different intracellular localizations, indicating that the isoforms may not be functionally equivalent in myelinating cells. The major MBPs (14 kD and 18.5 kD) have strong affinity for membranes, while on the other hand, the less abundant isoforms (17 kD and 21.5 kD) localize to the nucleus of young oligodendrocytes, suggesting a regulatory role in the myelination program. The same intracellular distribution patterns have been observed when the MBPs are expressed in Hela cells and in shiverer oligodendrocytes. Thus, the intracellular fate of these proteins seems to be generally directed through alternative expression of exon II. Furthermore, the extent of MBPexII entry into the nucleus was found to be directly related to the growth state of host cells. In this paper, we demonstrate that nuclear proteins constitutively expressed by Hela cells also exhibit an apparently growth-related nucleo-cytoplasmic distribution revealing that MBPexII exhibits the same behavior as bona fide nuclear proteins. Also, to further characterize MBP nuclear transport, we explored various parameters of the translocation of MBP into the nucleus using an in vitro system. This experimental paradigm permits the uncoupling of synthesis and translocation events; thus, the transport of MBP into cell nuclei can be studied as a function of time. We also evaluated how changes in temperature as well as energy depletion affect the in vitro nuclear transport of MBP. J. Neurosci. Res. 50:258–264, 1997. © 1997 Wiley-Liss, Inc." @default.
• W2048919163 created "2016-06-24" @default.
• W2048919163 creator A5042123888 @default.
• W2048919163 date "1997-10-15" @default.
• W2048919163 modified "2023-09-27" @default.
• W2048919163 title "Nuclear transport of myelin basic protein" @default.
• W2048919163 cites W1563617960 @default.
• W2048919163 cites W1618691523 @default.
• W2048919163 cites W1729152903 @default.
• W2048919163 cites W1877459447 @default.
• W2048919163 cites W1965638256 @default.
• W2048919163 cites W1984126072 @default.
• W2048919163 cites W2015139023 @default.
• W2048919163 cites W2031766817 @default.
• W2048919163 cites W2035091883 @default.
• W2048919163 cites W2036429346 @default.
• W2048919163 cites W2037463394 @default.
• W2048919163 cites W2042985028 @default.
• W2048919163 cites W2048755377 @default.
• W2048919163 cites W2061630160 @default.
• W2048919163 cites W2063499197 @default.
• W2048919163 cites W2066337898 @default.
• W2048919163 cites W2071606798 @default.
• W2048919163 cites W2079588047 @default.
• W2048919163 cites W2099304869 @default.
• W2048919163 cites W2125778361 @default.
• W2048919163 cites W2140365038 @default.
• W2048919163 cites W2157739247 @default.
• W2048919163 doi "https://doi.org/10.1002/(sici)1097-4547(19971015)50:2<258::aid-jnr14>3.0.co;2-4" @default.
• W2048919163 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9373035" @default.
• W2048919163 hasPublicationYear "1997" @default.
• W2048919163 type Work @default.
• W2048919163 sameAs 2048919163 @default.
• W2048919163 citedByCount "32" @default.
• W2048919163 countsByYear W20489191632012 @default.
• W2048919163 countsByYear W20489191632013 @default.
• W2048919163 countsByYear W20489191632014 @default.
• W2048919163 countsByYear W20489191632015 @default.
• W2048919163 countsByYear W20489191632016 @default.
• W2048919163 countsByYear W20489191632019 @default.
• W2048919163 countsByYear W20489191632020 @default.
• W2048919163 crossrefType "journal-article" @default.
• W2048919163 hasAuthorship W2048919163A5042123888 @default.
• W2048919163 hasConcept C104317684 @default.
• W2048919163 hasConcept C1491633281 @default.
• W2048919163 hasConcept C153911025 @default.
• W2048919163 hasConcept C169760540 @default.
• W2048919163 hasConcept C190062978 @default.
• W2048919163 hasConcept C2776985911 @default.
• W2048919163 hasConcept C2778609137 @default.
• W2048919163 hasConcept C2780064007 @default.
• W2048919163 hasConcept C2780114586 @default.
• W2048919163 hasConcept C2780723820 @default.
• W2048919163 hasConcept C2780876595 @default.
• W2048919163 hasConcept C29512474 @default.
• W2048919163 hasConcept C529278444 @default.
• W2048919163 hasConcept C53345823 @default.
• W2048919163 hasConcept C55493867 @default.
• W2048919163 hasConcept C59157529 @default.
• W2048919163 hasConcept C78885561 @default.
• W2048919163 hasConcept C79879829 @default.
• W2048919163 hasConcept C86339819 @default.
• W2048919163 hasConcept C86803240 @default.
• W2048919163 hasConcept C95444343 @default.
• W2048919163 hasConceptScore W2048919163C104317684 @default.
• W2048919163 hasConceptScore W2048919163C1491633281 @default.
• W2048919163 hasConceptScore W2048919163C153911025 @default.
• W2048919163 hasConceptScore W2048919163C169760540 @default.
• W2048919163 hasConceptScore W2048919163C190062978 @default.
• W2048919163 hasConceptScore W2048919163C2776985911 @default.
• W2048919163 hasConceptScore W2048919163C2778609137 @default.
• W2048919163 hasConceptScore W2048919163C2780064007 @default.
• W2048919163 hasConceptScore W2048919163C2780114586 @default.
• W2048919163 hasConceptScore W2048919163C2780723820 @default.
• W2048919163 hasConceptScore W2048919163C2780876595 @default.
• W2048919163 hasConceptScore W2048919163C29512474 @default.
• W2048919163 hasConceptScore W2048919163C529278444 @default.
• W2048919163 hasConceptScore W2048919163C53345823 @default.
• W2048919163 hasConceptScore W2048919163C55493867 @default.
• W2048919163 hasConceptScore W2048919163C59157529 @default.
• W2048919163 hasConceptScore W2048919163C78885561 @default.
• W2048919163 hasConceptScore W2048919163C79879829 @default.
• W2048919163 hasConceptScore W2048919163C86339819 @default.
• W2048919163 hasConceptScore W2048919163C86803240 @default.
• W2048919163 hasConceptScore W2048919163C95444343 @default.
• W2048919163 hasIssue "2" @default.
• W2048919163 hasLocation W20489191631 @default.
• W2048919163 hasLocation W20489191632 @default.
• W2048919163 hasOpenAccess W2048919163 @default.
• W2048919163 hasPrimaryLocation W20489191631 @default.
• W2048919163 hasRelatedWork W1502573407 @default.
• W2048919163 hasRelatedWork W1968930697 @default.
• W2048919163 hasRelatedWork W2048919163 @default.
• W2048919163 hasRelatedWork W2061630160 @default.
• W2048919163 hasRelatedWork W2092656729 @default.
• W2048919163 hasRelatedWork W2150112961 @default.
• W2048919163 hasRelatedWork W2160301054 @default.
• W2048919163 hasRelatedWork W2309934042 @default.

• next