Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048920512> ?p ?o ?g. }
- W2048920512 endingPage "77" @default.
- W2048920512 startingPage "69" @default.
- W2048920512 abstract "Currently, no effective treatment for malignant pheochromocytoma exists. The aim of our study was to investigate the role of chromogranin A (CgA) as a specific target molecule for immunotherapy in a murine model for pheochromocytoma. Six amino acid-modified and non-modified CgA peptides were used for dendritic cell vaccination. Altogether, 50 mice received two different CgA vaccination protocols; another 20 animals served as controls. In vitro tetramer analyses revealed large increases of CgA-specific cytotoxic T cells (CTL) in CgA-treated mice. Tumors of exogenous applied pheochromocytoma cells showed an extensive infiltration by CD8+ T cells. In vitro, CTL of CgA-treated mice exhibited strong MHC I restricted lysis capacities towards pheochromocytoma cells. Importantly, these mice showed strongly diminished outgrowth of liver tumors of applied pheochromocytoma cells. Our data clearly demonstrate that CgA peptide-based immunotherapy induces a cytotoxic immune response in experimental pheochromocytoma, indicating potential for therapeutic applications in patients with malignant pheochromocytoma." @default.
- W2048920512 created "2016-06-24" @default.
- W2048920512 creator A5006906048 @default.
- W2048920512 creator A5007171110 @default.
- W2048920512 creator A5009071033 @default.
- W2048920512 creator A5014384048 @default.
- W2048920512 creator A5022629708 @default.
- W2048920512 creator A5024077602 @default.
- W2048920512 creator A5026699579 @default.
- W2048920512 creator A5038260905 @default.
- W2048920512 creator A5038535459 @default.
- W2048920512 creator A5040525151 @default.
- W2048920512 creator A5046768397 @default.
- W2048920512 creator A5056291023 @default.
- W2048920512 creator A5057117005 @default.
- W2048920512 creator A5087640253 @default.
- W2048920512 date "2011-03-01" @default.
- W2048920512 modified "2023-09-27" @default.
- W2048920512 title "Chromogranin A as potential target for immunotherapy of malignant pheochromocytoma" @default.
- W2048920512 cites W1534934956 @default.
- W2048920512 cites W1903486456 @default.
- W2048920512 cites W1965532783 @default.
- W2048920512 cites W1969117389 @default.
- W2048920512 cites W1979676217 @default.
- W2048920512 cites W1982938784 @default.
- W2048920512 cites W1987762499 @default.
- W2048920512 cites W1988604479 @default.
- W2048920512 cites W1994048581 @default.
- W2048920512 cites W1997563646 @default.
- W2048920512 cites W1999042146 @default.
- W2048920512 cites W2014783562 @default.
- W2048920512 cites W2019349075 @default.
- W2048920512 cites W2026171006 @default.
- W2048920512 cites W2032457962 @default.
- W2048920512 cites W2032516847 @default.
- W2048920512 cites W2032975856 @default.
- W2048920512 cites W2042145190 @default.
- W2048920512 cites W2042380240 @default.
- W2048920512 cites W2044135873 @default.
- W2048920512 cites W2047377397 @default.
- W2048920512 cites W2047382244 @default.
- W2048920512 cites W2050227969 @default.
- W2048920512 cites W2052357793 @default.
- W2048920512 cites W2062296974 @default.
- W2048920512 cites W2062871577 @default.
- W2048920512 cites W2064454796 @default.
- W2048920512 cites W2077215890 @default.
- W2048920512 cites W2079243945 @default.
- W2048920512 cites W2082432158 @default.
- W2048920512 cites W2093947505 @default.
- W2048920512 cites W2094373150 @default.
- W2048920512 cites W2101485657 @default.
- W2048920512 cites W2104525960 @default.
- W2048920512 cites W2109613286 @default.
- W2048920512 cites W2119235043 @default.
- W2048920512 cites W2130311074 @default.
- W2048920512 cites W2140820953 @default.
- W2048920512 cites W2141249284 @default.
- W2048920512 cites W2162178643 @default.
- W2048920512 cites W2163713464 @default.
- W2048920512 cites W2169325472 @default.
- W2048920512 cites W2228796536 @default.
- W2048920512 cites W2319457872 @default.
- W2048920512 doi "https://doi.org/10.1016/j.mce.2010.05.021" @default.
- W2048920512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20600588" @default.
- W2048920512 hasPublicationYear "2011" @default.
- W2048920512 type Work @default.
- W2048920512 sameAs 2048920512 @default.
- W2048920512 citedByCount "6" @default.
- W2048920512 countsByYear W20489205122012 @default.
- W2048920512 countsByYear W20489205122014 @default.
- W2048920512 countsByYear W20489205122016 @default.
- W2048920512 countsByYear W20489205122019 @default.
- W2048920512 countsByYear W20489205122022 @default.
- W2048920512 crossrefType "journal-article" @default.
- W2048920512 hasAuthorship W2048920512A5006906048 @default.
- W2048920512 hasAuthorship W2048920512A5007171110 @default.
- W2048920512 hasAuthorship W2048920512A5009071033 @default.
- W2048920512 hasAuthorship W2048920512A5014384048 @default.
- W2048920512 hasAuthorship W2048920512A5022629708 @default.
- W2048920512 hasAuthorship W2048920512A5024077602 @default.
- W2048920512 hasAuthorship W2048920512A5026699579 @default.
- W2048920512 hasAuthorship W2048920512A5038260905 @default.
- W2048920512 hasAuthorship W2048920512A5038535459 @default.
- W2048920512 hasAuthorship W2048920512A5040525151 @default.
- W2048920512 hasAuthorship W2048920512A5046768397 @default.
- W2048920512 hasAuthorship W2048920512A5056291023 @default.
- W2048920512 hasAuthorship W2048920512A5057117005 @default.
- W2048920512 hasAuthorship W2048920512A5087640253 @default.
- W2048920512 hasConcept C126322002 @default.
- W2048920512 hasConcept C147969180 @default.
- W2048920512 hasConcept C154317977 @default.
- W2048920512 hasConcept C167672396 @default.
- W2048920512 hasConcept C202751555 @default.
- W2048920512 hasConcept C203014093 @default.
- W2048920512 hasConcept C204232928 @default.
- W2048920512 hasConcept C2777701055 @default.
- W2048920512 hasConcept C2779512018 @default.