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• W2048928608 abstract "Abstract— Chloroaluminum phthalocyanine (CAPC) is an efficient photosensitizer for the inactivation of Chinese hamster V79 cells. In order to investigate possible molecular mechanisms in the photo-dynamic action of CAPC and visible light, the induction and repair rate of two classes of DNA lesions have been determined, i.e. DNA single-strand breaks and DNA-protein cross-links. In cells pretreated with 1 μ.M CAPC, a fluence of 12 kJ/m2 of red light (>600 nm) kills approximately 50% of the cells and induces 3 to 3.5 Gy-equivalents of single-strand breaks. The repair of these breaks was slower than the repair of single-strand breaks induced by m̀-irradiation. The photodynamic action of CAPC also induces a large number of DNA-protein cross-links which, in contrast to m̀-radiation-induced DNA-protein cross-links, do not appear to be repaired during 4 h of post-treatment incubation in fresh medium. These studies suggest that DNA may be an important target for the cytotoxicity of CAPC + red light." @default.
• W2048928608 created "2016-06-24" @default.
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• W2048928608 date "1988-09-01" @default.
• W2048928608 modified "2023-10-14" @default.
• W2048928608 title "INDUCTION OF DNA-PROTEIN CROSS-LINKS IN CHINESE HAMSTER CELLS BY THE PHOTODYNAMIC ACTION OF CHLOROALUMINUM PHTHALOCYANINE AND VISIBLE LIGHT" @default.
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• W2048928608 doi "https://doi.org/10.1111/j.1751-1097.1988.tb02824.x" @default.
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