FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048932685> ?p ?o ?g. }

• W2048932685 abstract "Background The resistance to chemotherapy is a major obstacle in the treatment of hepatocellular carcinoma (HCC), necessitating the discovery of additional agents. The use of natural products in this respect is extensively under investigation. Methods Two hundred and ten male albino rats were used, divided into 14 groups. Selected groups were pre-treated with vitamin C (ascorbic acid, AA) and/or diallyl sulphide (DAS). Hepatocellular dysplasia was initiated by a single intra-peritoneal (IP) injection of diethyl nitrosamine (DENA), diabetes was induced by a single IP injection of Streptozotocin (STZ). Other groups were treated with cisplatin (CP) alone or combined with AA and/or DAS for 14 weeks. This work aims to check if naturally occurring materials can help in improving response to CP chemotherapy using ploylol profile as a new index in management of HCC. Results The results revealed that DENA significantly increased relative liver weight, serum ALT, AST and GGT activities, AFP, TNF-α and IL-6 levels, expression of aldose reductase (AR), sorbitol dehydrogenase (SDH) and Bcl2 proteins in the liver with decrease in body weight, expression of Bax protein and Bax/Bcl2 ratio in the liver. These effects were more pronounced in DENA+STZ group. These parameters showed relative correlation to AFP levels in HCC, in response to AA and/or DAS treatment except for SDH. Treatment with CP and/or AA and/or DAS significantly modulated most of these parameters except for SDH which showed no significant change in response to the suggested treatment. Conclusions In conclusion, AA and/or DAS showed apparent chemo-sensitizing, anti-inflammatory, AR inhibitory, apoptotic inducing and anti-diabetic activities, indicating new aspects for use as adjuvant to chemotherapy. Induction of diabetes in hepatocellular dysplasia -bearing rats showed higher resistance to chemotherapy. Ploylol profile is a useful prognostic tool in HCC patients with diabetic interference." @default.
• W2048932685 created "2016-06-24" @default.
• W2048932685 creator A5045625402 @default.
• W2048932685 creator A5055971813 @default.
• W2048932685 creator A5056320259 @default.
• W2048932685 date "2011-11-23" @default.
• W2048932685 modified "2023-09-25" @default.
• W2048932685 title "Vitamin C and diallyl sulfide as chemosensitizers to cisplatin in treating hepatocellular carcinoma" @default.
• W2048932685 cites W128929951 @default.
• W2048932685 cites W131367607 @default.
• W2048932685 cites W147439079 @default.
• W2048932685 cites W1584378357 @default.
• W2048932685 cites W1591682143 @default.
• W2048932685 cites W182700988 @default.
• W2048932685 cites W1956950605 @default.
• W2048932685 cites W1973286934 @default.
• W2048932685 cites W1988417968 @default.
• W2048932685 cites W1989171624 @default.
• W2048932685 cites W1992240979 @default.
• W2048932685 cites W1996719655 @default.
• W2048932685 cites W1997823664 @default.
• W2048932685 cites W1999540984 @default.
• W2048932685 cites W2005077370 @default.
• W2048932685 cites W2005798625 @default.
• W2048932685 cites W2009663184 @default.
• W2048932685 cites W2012955594 @default.
• W2048932685 cites W2014742104 @default.
• W2048932685 cites W2020488804 @default.
• W2048932685 cites W2021761439 @default.
• W2048932685 cites W2036214134 @default.
• W2048932685 cites W2039718015 @default.
• W2048932685 cites W2039784103 @default.
• W2048932685 cites W2043497955 @default.
• W2048932685 cites W2048700223 @default.
• W2048932685 cites W2056841084 @default.
• W2048932685 cites W2057911248 @default.
• W2048932685 cites W2060562628 @default.
• W2048932685 cites W2063303943 @default.
• W2048932685 cites W2073131323 @default.
• W2048932685 cites W2076725650 @default.
• W2048932685 cites W2077970396 @default.
• W2048932685 cites W2083871561 @default.
• W2048932685 cites W2086681374 @default.
• W2048932685 cites W2113179577 @default.
• W2048932685 cites W2116508147 @default.
• W2048932685 cites W2119115728 @default.
• W2048932685 cites W2128635872 @default.
• W2048932685 cites W2129292423 @default.
• W2048932685 cites W2136484116 @default.
• W2048932685 cites W2137799951 @default.
• W2048932685 cites W2153830860 @default.
• W2048932685 cites W2161427454 @default.
• W2048932685 cites W2161964115 @default.
• W2048932685 cites W2172085921 @default.
• W2048932685 cites W2229279525 @default.
• W2048932685 cites W2263830966 @default.
• W2048932685 cites W2403501372 @default.
• W2048932685 cites W2412343408 @default.
• W2048932685 cites W2444323037 @default.
• W2048932685 cites W77720024 @default.
• W2048932685 doi "https://doi.org/10.5430/jst.v1n3p90" @default.
• W2048932685 hasPublicationYear "2011" @default.
• W2048932685 type Work @default.
• W2048932685 sameAs 2048932685 @default.
• W2048932685 citedByCount "7" @default.
• W2048932685 countsByYear W20489326852017 @default.
• W2048932685 countsByYear W20489326852018 @default.
• W2048932685 countsByYear W20489326852019 @default.
• W2048932685 countsByYear W20489326852021 @default.
• W2048932685 countsByYear W20489326852022 @default.
• W2048932685 crossrefType "journal-article" @default.
• W2048932685 hasAuthorship W2048932685A5045625402 @default.
• W2048932685 hasAuthorship W2048932685A5055971813 @default.
• W2048932685 hasAuthorship W2048932685A5056320259 @default.
• W2048932685 hasBestOaLocation W20489326851 @default.
• W2048932685 hasConcept C126322002 @default.
• W2048932685 hasConcept C134018914 @default.
• W2048932685 hasConcept C185592680 @default.
• W2048932685 hasConcept C2776694085 @default.
• W2048932685 hasConcept C2776779347 @default.
• W2048932685 hasConcept C2777905771 @default.
• W2048932685 hasConcept C2778019345 @default.
• W2048932685 hasConcept C2778239845 @default.
• W2048932685 hasConcept C2779280383 @default.
• W2048932685 hasConcept C2780022331 @default.
• W2048932685 hasConcept C2986274086 @default.
• W2048932685 hasConcept C31903555 @default.
• W2048932685 hasConcept C55493867 @default.
• W2048932685 hasConcept C555293320 @default.
• W2048932685 hasConcept C71924100 @default.
• W2048932685 hasConcept C90924648 @default.
• W2048932685 hasConcept C98274493 @default.
• W2048932685 hasConceptScore W2048932685C126322002 @default.
• W2048932685 hasConceptScore W2048932685C134018914 @default.
• W2048932685 hasConceptScore W2048932685C185592680 @default.
• W2048932685 hasConceptScore W2048932685C2776694085 @default.
• W2048932685 hasConceptScore W2048932685C2776779347 @default.
• W2048932685 hasConceptScore W2048932685C2777905771 @default.
• W2048932685 hasConceptScore W2048932685C2778019345 @default.
• W2048932685 hasConceptScore W2048932685C2778239845 @default.

• next