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- W2048936622 abstract "Misfolded microtubule-associated neuronal protein tau is regarded as a prime iniciator of neurodegeneration in human tauopathies. It is believed that seminal posttranslational events leading to the transition of tau protein from disordered to misordered state are associated with increased phosphorylation or truncation or a combination of the two. Recently, we have presented a rat model of Alzheimer's disease expressing a truncated tau form derived from human sporadic AD, which exhibits drastically reduced survival caused by severe neuronal degeneration. This work revealed the toxic properties of misfolded tau protein. We have analyzed the endogenous rat tau and the misfolded (truncated) human tau expressed in the brain of the transgenic animals by Western blotting with phospho-tau specific antibodies. We found that only misfolded tau protein is hyperphosphorylated on several Ser and Thr residues during the whole life of the transgenic animals. On the other hand, phosphorylated forms of the endogenous rat tau disappeared within 3 weeks after birth in both wt and transgenic animals. Furthermore, misfolded tau negatively influenced the phosphorylation level of endogenous tau, suggesting a competition between the tau forms (substrates) for kinases. Gene expression analysis of transgenic and wild type rat brains has shown that neither upregulation of kinases nor downregulation of phosphatases takes place in these transgenic animals. Based on our results we conclude that hyperphosphorylation of a misfolded tau is driven by its conformation, which is distinct from that of a normal tau protein, and not by an increased activity of kinases. Acknowledgement: The work was supported by a grant from Axon Neuroscience and the Slovak grant agency APVV, grants number LPP 326-06, APVV VV 603-06 and VEGA 2/7129/27." @default.
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- W2048936622 date "2009-07-01" @default.
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- W2048936622 title "P3-201: Molecular analysis of tau phosphorylation in a rat model of Alzheimer's disease revealed interplay between the endogenous rat tau and misfolded human Alzheimer's disease derived tau" @default.
- W2048936622 doi "https://doi.org/10.1016/j.jalz.2009.04.974" @default.
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