FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048942013> ?p ?o ?g. }

• W2048942013 endingPage "1628" @default.
• W2048942013 startingPage "1619" @default.
• W2048942013 abstract "MIR-491 is commonly co-deleted with its adjacent CDKN2A on chromosome 9p21.3 in glioblastoma multiforme (GBM). However, it is not known whether deletion of MIR-491 is only a passenger event or has an important role. Small-RNA sequencing of samples from GBM patients demonstrated that both mature products of MIR-491 (miR-491-5p and -3p) are downregulated in tumors compared with the normal brain. The integration of GBM data from The Cancer Genome Atlas (TCGA), miRNA target prediction and reporter assays showed that miR-491-5p directly targets EGFR, CDK6 and Bcl-xL, whereas miR-491-3p targets IGFBP2 and CDK6. Functionally, miR-491-3p inhibited glioma cell invasion; overexpression of both miR-491-5p and -3p inhibited proliferation of glioma cell lines and impaired the propagation of glioma stem cells (GSCs), thereby prolonging survival of xenograft mice. Moreover, knockdown of miR-491-5p in primary Ink4a-Arf-null mouse glial progenitor cells exacerbated cell proliferation and invasion. Therefore, MIR-491 is a tumor suppressor gene that, by utilizing both mature forms, coordinately controls the key cancer hallmarks: proliferation, invasion and stem cell propagation." @default.
• W2048942013 created "2016-06-24" @default.
• W2048942013 creator A5011772554 @default.
• W2048942013 creator A5012403937 @default.
• W2048942013 creator A5013938672 @default.
• W2048942013 creator A5026241338 @default.
• W2048942013 creator A5052110149 @default.
• W2048942013 creator A5054809773 @default.
• W2048942013 creator A5055112441 @default.
• W2048942013 creator A5061460061 @default.
• W2048942013 creator A5063194021 @default.
• W2048942013 creator A5066614473 @default.
• W2048942013 creator A5070740355 @default.
• W2048942013 creator A5072080566 @default.
• W2048942013 creator A5077727552 @default.
• W2048942013 creator A5079533477 @default.
• W2048942013 creator A5079738340 @default.
• W2048942013 date "2014-04-21" @default.
• W2048942013 modified "2023-10-12" @default.
• W2048942013 title "Two mature products of MIR-491 coordinate to suppress key cancer hallmarks in glioblastoma" @default.
• W2048942013 cites W1553966318 @default.
• W2048942013 cites W1794612623 @default.
• W2048942013 cites W1904552623 @default.
• W2048942013 cites W1964794425 @default.
• W2048942013 cites W1965225032 @default.
• W2048942013 cites W1965714535 @default.
• W2048942013 cites W1985129470 @default.
• W2048942013 cites W1985148439 @default.
• W2048942013 cites W1988070337 @default.
• W2048942013 cites W2001544973 @default.
• W2048942013 cites W2002995168 @default.
• W2048942013 cites W2005505016 @default.
• W2048942013 cites W2013005452 @default.
• W2048942013 cites W2018671779 @default.
• W2048942013 cites W2018863770 @default.
• W2048942013 cites W2025183726 @default.
• W2048942013 cites W2033932082 @default.
• W2048942013 cites W2038407368 @default.
• W2048942013 cites W2039356709 @default.
• W2048942013 cites W2047480689 @default.
• W2048942013 cites W2049553483 @default.
• W2048942013 cites W2054745930 @default.
• W2048942013 cites W2054961220 @default.
• W2048942013 cites W2056307371 @default.
• W2048942013 cites W2066562900 @default.
• W2048942013 cites W2081069777 @default.
• W2048942013 cites W2087296361 @default.
• W2048942013 cites W2094641772 @default.
• W2048942013 cites W2094963389 @default.
• W2048942013 cites W2099099087 @default.
• W2048942013 cites W2099316383 @default.
• W2048942013 cites W2105279254 @default.
• W2048942013 cites W2107591555 @default.
• W2048942013 cites W2111375311 @default.
• W2048942013 cites W2111650991 @default.
• W2048942013 cites W2111969156 @default.
• W2048942013 cites W2113579151 @default.
• W2048942013 cites W2117692326 @default.
• W2048942013 cites W2117941094 @default.
• W2048942013 cites W2118961709 @default.
• W2048942013 cites W2124476064 @default.
• W2048942013 cites W2131616553 @default.
• W2048942013 cites W2137047140 @default.
• W2048942013 cites W2138448120 @default.
• W2048942013 cites W2139203226 @default.
• W2048942013 cites W2143471040 @default.
• W2048942013 cites W2147730829 @default.
• W2048942013 cites W2150522342 @default.
• W2048942013 cites W2154073395 @default.
• W2048942013 cites W2154533634 @default.
• W2048942013 cites W2161289668 @default.
• W2048942013 cites W2162674813 @default.
• W2048942013 cites W2165027097 @default.
• W2048942013 cites W2167650288 @default.
• W2048942013 cites W2168557205 @default.
• W2048942013 cites W2412936254 @default.
• W2048942013 cites W2597632520 @default.
• W2048942013 doi "https://doi.org/10.1038/onc.2014.98" @default.
• W2048942013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4205227" @default.
• W2048942013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24747968" @default.
• W2048942013 hasPublicationYear "2014" @default.
• W2048942013 type Work @default.
• W2048942013 sameAs 2048942013 @default.
• W2048942013 citedByCount "80" @default.
• W2048942013 countsByYear W20489420132014 @default.
• W2048942013 countsByYear W20489420132015 @default.
• W2048942013 countsByYear W20489420132016 @default.
• W2048942013 countsByYear W20489420132017 @default.
• W2048942013 countsByYear W20489420132018 @default.
• W2048942013 countsByYear W20489420132019 @default.
• W2048942013 countsByYear W20489420132020 @default.
• W2048942013 countsByYear W20489420132021 @default.
• W2048942013 countsByYear W20489420132022 @default.
• W2048942013 countsByYear W20489420132023 @default.
• W2048942013 crossrefType "journal-article" @default.
• W2048942013 hasAuthorship W2048942013A5011772554 @default.
• W2048942013 hasAuthorship W2048942013A5012403937 @default.
• W2048942013 hasAuthorship W2048942013A5013938672 @default.

• next