FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048962022> ?p ?o ?g. }

• W2048962022 endingPage "254" @default.
• W2048962022 startingPage "248" @default.
• W2048962022 abstract "The present study is designed to explore the anti-inflammatory potential of Aegiceras corniculatum Linn. Blanco stems extracts and their mechanism of action against various pro-inflammatory mediators and to validate its traditional use against inflammatory diseases.Rat paw edema and peritonitis models were employed for in vivo studies. For in vitro studies human platelets and rat neutrophils were stimulated with Ca(2+)-ionophore A23187 leading to the production of various pro-inflammatory metabolites, i.e., 12-HTT, 12-HETE and LTB(4) and 5-HETE which were quantified by HPLC.The highly polar methanol extract (100mg/kg) caused approximately 90% reduction in the carrageenan- and prostaglandin E2-induced paw edema in rats. It also caused the inhibition of cycloxygenase-1 metabolite, 12-HHT (IC(50) 41.1+/-1.5microg/ml) with a concomitant rise in 12-lipoxygenase metabolite, 12-HETE in A23187 stimulated human platelets. Conversely, the non-polar hexane extract attenuated (IC(50) 0.36+/-0.12microg/ml) 12-HETE formation with a parallel rise in 12-HHT, thereby displaying a selectivity towards 12-lipoxygenase. Non-polar hexane extract also antagonized the production of 5-lipoxygenase metabolites, i.e., leukotriene B(4) and 5-HETE in the rat neutrophils. Furthermore, ethyl acetate extract inhibited both COX and 5-LOX with a marked decline in the production of 12-HHT (IC(50) 0.08+/-0.002microg/ml) and LTB(4) (IC(50) 0.86+/-0.03microg/ml), respectively. The anti-inflammatory effect of hexane and ethyl acetate extracts was also reflected by the diminution of carrageenan-induced cell infiltration in rat peritoneum. Additionally, plant extracts caused approximately 60% suppression in dextran-induced paw edema implying that they also ameliorate histamine and serotonin release.Hexane, ethyl acetate and methanol extracts derived from Aegiceras corniculatum possess significant anti-inflammatory activity via multiple mechanisms and validate their traditional use against inflammation-related diseases." @default.
• W2048962022 created "2016-06-24" @default.
• W2048962022 creator A5004656083 @default.
• W2048962022 creator A5024358392 @default.
• W2048962022 creator A5040577138 @default.
• W2048962022 creator A5057044175 @default.
• W2048962022 creator A5060545417 @default.
• W2048962022 date "2008-11-01" @default.
• W2048962022 modified "2023-10-16" @default.
• W2048962022 title "Aegiceras corniculatum extract suppresses initial and late phases of inflammation in rat paw and attenuates the production of eicosanoids in rat neutrophils and human platelets" @default.
• W2048962022 cites W1487532570 @default.
• W2048962022 cites W1528588273 @default.
• W2048962022 cites W1538373456 @default.
• W2048962022 cites W1966282630 @default.
• W2048962022 cites W1970652854 @default.
• W2048962022 cites W1981819970 @default.
• W2048962022 cites W1988889626 @default.
• W2048962022 cites W1995600688 @default.
• W2048962022 cites W1996462445 @default.
• W2048962022 cites W2000346583 @default.
• W2048962022 cites W2005482463 @default.
• W2048962022 cites W2015510086 @default.
• W2048962022 cites W2024064426 @default.
• W2048962022 cites W2036056925 @default.
• W2048962022 cites W2051996465 @default.
• W2048962022 cites W2052910548 @default.
• W2048962022 cites W2054789114 @default.
• W2048962022 cites W2056879548 @default.
• W2048962022 cites W2064144934 @default.
• W2048962022 cites W2065277720 @default.
• W2048962022 cites W2074793023 @default.
• W2048962022 cites W2082987125 @default.
• W2048962022 cites W2082997350 @default.
• W2048962022 cites W2091235061 @default.
• W2048962022 cites W2123833658 @default.
• W2048962022 cites W2134799079 @default.
• W2048962022 cites W2325796334 @default.
• W2048962022 cites W932890253 @default.
• W2048962022 doi "https://doi.org/10.1016/j.jep.2008.08.025" @default.
• W2048962022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18809484" @default.
• W2048962022 hasPublicationYear "2008" @default.
• W2048962022 type Work @default.
• W2048962022 sameAs 2048962022 @default.
• W2048962022 citedByCount "23" @default.
• W2048962022 countsByYear W20489620222012 @default.
• W2048962022 countsByYear W20489620222014 @default.
• W2048962022 countsByYear W20489620222016 @default.
• W2048962022 countsByYear W20489620222017 @default.
• W2048962022 countsByYear W20489620222018 @default.
• W2048962022 countsByYear W20489620222019 @default.
• W2048962022 countsByYear W20489620222020 @default.
• W2048962022 countsByYear W20489620222021 @default.
• W2048962022 countsByYear W20489620222022 @default.
• W2048962022 countsByYear W20489620222023 @default.
• W2048962022 crossrefType "journal-article" @default.
• W2048962022 hasAuthorship W2048962022A5004656083 @default.
• W2048962022 hasAuthorship W2048962022A5024358392 @default.
• W2048962022 hasAuthorship W2048962022A5040577138 @default.
• W2048962022 hasAuthorship W2048962022A5057044175 @default.
• W2048962022 hasAuthorship W2048962022A5060545417 @default.
• W2048962022 hasConcept C126322002 @default.
• W2048962022 hasConcept C150903083 @default.
• W2048962022 hasConcept C181199279 @default.
• W2048962022 hasConcept C185592680 @default.
• W2048962022 hasConcept C207001950 @default.
• W2048962022 hasConcept C2776352991 @default.
• W2048962022 hasConcept C2776685179 @default.
• W2048962022 hasConcept C2776914184 @default.
• W2048962022 hasConcept C2777361909 @default.
• W2048962022 hasConcept C2777477808 @default.
• W2048962022 hasConcept C2778078955 @default.
• W2048962022 hasConcept C2780664492 @default.
• W2048962022 hasConcept C2780857362 @default.
• W2048962022 hasConcept C55493867 @default.
• W2048962022 hasConcept C71924100 @default.
• W2048962022 hasConcept C86803240 @default.
• W2048962022 hasConcept C90342290 @default.
• W2048962022 hasConcept C98274493 @default.
• W2048962022 hasConceptScore W2048962022C126322002 @default.
• W2048962022 hasConceptScore W2048962022C150903083 @default.
• W2048962022 hasConceptScore W2048962022C181199279 @default.
• W2048962022 hasConceptScore W2048962022C185592680 @default.
• W2048962022 hasConceptScore W2048962022C207001950 @default.
• W2048962022 hasConceptScore W2048962022C2776352991 @default.
• W2048962022 hasConceptScore W2048962022C2776685179 @default.
• W2048962022 hasConceptScore W2048962022C2776914184 @default.
• W2048962022 hasConceptScore W2048962022C2777361909 @default.
• W2048962022 hasConceptScore W2048962022C2777477808 @default.
• W2048962022 hasConceptScore W2048962022C2778078955 @default.
• W2048962022 hasConceptScore W2048962022C2780664492 @default.
• W2048962022 hasConceptScore W2048962022C2780857362 @default.
• W2048962022 hasConceptScore W2048962022C55493867 @default.
• W2048962022 hasConceptScore W2048962022C71924100 @default.
• W2048962022 hasConceptScore W2048962022C86803240 @default.
• W2048962022 hasConceptScore W2048962022C90342290 @default.
• W2048962022 hasConceptScore W2048962022C98274493 @default.
• W2048962022 hasIssue "2" @default.
• W2048962022 hasLocation W20489620221 @default.

• next