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- W2048966920 abstract "The best characterized examples of crosstalk between two or more different post-translational modifications (PTMs) occur with respect to histones. These examples demonstrate the critical roles that crosstalk plays in regulating cell signaling pathways. Recently, however, non-histone crosstalk has been observed between serine/threonine phosphorylation and the modification of arginine and lysine residues within kinase consensus sequences. Interestingly, many kinase consensus sequences contain critical arginine/lysine residues surrounding the substrate serine/threonine residue. Therefore, we hypothesize that non-histone crosstalk between serine/threonine phosphorylation and arginine/lysine modifications is a global mechanism for the modulation of cellular signaling. In this review, we discuss several recent examples of non-histone kinase consensus sequence crosstalk, as well as provide the biophysical basis for these observations. In addition, we predict likely examples of crosstalk between protein arginine methyltransferase 1 (PRMT1) and Akt and discuss the future implications of these findings." @default.
- W2048966920 created "2016-06-24" @default.
- W2048966920 creator A5028762728 @default.
- W2048966920 creator A5059551211 @default.
- W2048966920 date "2011-07-15" @default.
- W2048966920 modified "2023-10-16" @default.
- W2048966920 title "Kinase Consensus Sequences: A Breeding Ground for Crosstalk" @default.
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- W2048966920 doi "https://doi.org/10.1021/cb200171d" @default.
- W2048966920 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3176959" @default.
- W2048966920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21721511" @default.
- W2048966920 hasPublicationYear "2011" @default.
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