FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048975846> ?p ?o ?g. }

• W2048975846 endingPage "8178" @default.
• W2048975846 startingPage "8173" @default.
• W2048975846 abstract "To explore the possibility that overproduction of neuronal acetylcholinesterase (AChE) confers changes in both cholinergic and morphogenic intercellular interactions, we studied developmental responses to neuronal AChE overexpression in motoneurons and neuromuscular junctions of AChE-transgenic mice. Perikarya of spinal cord motoneurons were consistently enlarged from embryonic through adult stages in AChE-transgenic mice. Atypical motoneuron development was accompanied by premature enhancement in the embryonic spinal cord expression of choline acetyltransferase mRNA, encoding the acetylcholine-synthesizing enzyme choline acetyltransferase. In contrast, the mRNA encoding for neurexin-Iβ, the heterophilic ligand of the AChE-homologous neuronal cell surface protein neuroligin, was drastically lower in embryonic transgenic spinal cord than in controls. Postnatal cessation of these dual transcriptional responses was followed by late-onset deterioration in neuromotor performance that was associated with gross aberrations in neuromuscular ultrastructure and with pronounced amyotrophy. These findings demonstrate embryonic feedback mechanisms to neuronal AChE overexpression that are attributable to both cholinergic and cell–cell interaction pathways, suggesting that embryonic neurexin Iβ expression is concerted in vivo with AChE levels and indicating that postnatal changes in neuronal AChE-associated proteins may be involved in late-onset neuromotor pathologies." @default.
• W2048975846 created "2016-06-24" @default.
• W2048975846 creator A5003585109 @default.
• W2048975846 creator A5003680413 @default.
• W2048975846 creator A5026748669 @default.
• W2048975846 creator A5041715206 @default.
• W2048975846 creator A5045533073 @default.
• W2048975846 creator A5045895671 @default.
• W2048975846 creator A5063925465 @default.
• W2048975846 creator A5087592785 @default.
• W2048975846 date "1997-07-22" @default.
• W2048975846 modified "2023-09-23" @default.
• W2048975846 title "Acetylcholinesterase-transgenic mice display embryonic modulations in spinal cord choline acetyltransferase and neurexin Iβ gene expression followed by late-onset neuromotor deterioration" @default.
• W2048975846 cites W1539488577 @default.
• W2048975846 cites W1544919124 @default.
• W2048975846 cites W1557084204 @default.
• W2048975846 cites W1559702432 @default.
• W2048975846 cites W1977318067 @default.
• W2048975846 cites W1977592017 @default.
• W2048975846 cites W1989541223 @default.
• W2048975846 cites W1990907625 @default.
• W2048975846 cites W1993415479 @default.
• W2048975846 cites W2002068275 @default.
• W2048975846 cites W2009883535 @default.
• W2048975846 cites W2015262258 @default.
• W2048975846 cites W2045507768 @default.
• W2048975846 cites W2061641125 @default.
• W2048975846 cites W2064352628 @default.
• W2048975846 cites W2074576411 @default.
• W2048975846 cites W2077207000 @default.
• W2048975846 cites W2078005927 @default.
• W2048975846 cites W2080324921 @default.
• W2048975846 cites W2095438940 @default.
• W2048975846 cites W2100150264 @default.
• W2048975846 cites W2109976139 @default.
• W2048975846 cites W2146681797 @default.
• W2048975846 cites W2160618980 @default.
• W2048975846 cites W2225186704 @default.
• W2048975846 doi "https://doi.org/10.1073/pnas.94.15.8173" @default.
• W2048975846 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/21576" @default.
• W2048975846 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9223334" @default.
• W2048975846 hasPublicationYear "1997" @default.
• W2048975846 type Work @default.
• W2048975846 sameAs 2048975846 @default.
• W2048975846 citedByCount "72" @default.
• W2048975846 countsByYear W20489758462013 @default.
• W2048975846 countsByYear W20489758462014 @default.
• W2048975846 countsByYear W20489758462015 @default.
• W2048975846 countsByYear W20489758462018 @default.
• W2048975846 countsByYear W20489758462021 @default.
• W2048975846 crossrefType "journal-article" @default.
• W2048975846 hasAuthorship W2048975846A5003585109 @default.
• W2048975846 hasAuthorship W2048975846A5003680413 @default.
• W2048975846 hasAuthorship W2048975846A5026748669 @default.
• W2048975846 hasAuthorship W2048975846A5041715206 @default.
• W2048975846 hasAuthorship W2048975846A5045533073 @default.
• W2048975846 hasAuthorship W2048975846A5045895671 @default.
• W2048975846 hasAuthorship W2048975846A5063925465 @default.
• W2048975846 hasAuthorship W2048975846A5087592785 @default.
• W2048975846 hasBestOaLocation W20489758462 @default.
• W2048975846 hasConcept C102230213 @default.
• W2048975846 hasConcept C104317684 @default.
• W2048975846 hasConcept C112592302 @default.
• W2048975846 hasConcept C126322002 @default.
• W2048975846 hasConcept C134018914 @default.
• W2048975846 hasConcept C141035611 @default.
• W2048975846 hasConcept C145103041 @default.
• W2048975846 hasConcept C169760540 @default.
• W2048975846 hasConcept C170493617 @default.
• W2048975846 hasConcept C17077164 @default.
• W2048975846 hasConcept C181199279 @default.
• W2048975846 hasConcept C197341189 @default.
• W2048975846 hasConcept C198399640 @default.
• W2048975846 hasConcept C22885893 @default.
• W2048975846 hasConcept C2775910092 @default.
• W2048975846 hasConcept C2777240379 @default.
• W2048975846 hasConcept C2778162979 @default.
• W2048975846 hasConcept C2778816929 @default.
• W2048975846 hasConcept C2779790309 @default.
• W2048975846 hasConcept C55493867 @default.
• W2048975846 hasConcept C71924100 @default.
• W2048975846 hasConcept C86803240 @default.
• W2048975846 hasConcept C95444343 @default.
• W2048975846 hasConceptScore W2048975846C102230213 @default.
• W2048975846 hasConceptScore W2048975846C104317684 @default.
• W2048975846 hasConceptScore W2048975846C112592302 @default.
• W2048975846 hasConceptScore W2048975846C126322002 @default.
• W2048975846 hasConceptScore W2048975846C134018914 @default.
• W2048975846 hasConceptScore W2048975846C141035611 @default.
• W2048975846 hasConceptScore W2048975846C145103041 @default.
• W2048975846 hasConceptScore W2048975846C169760540 @default.
• W2048975846 hasConceptScore W2048975846C170493617 @default.
• W2048975846 hasConceptScore W2048975846C17077164 @default.
• W2048975846 hasConceptScore W2048975846C181199279 @default.
• W2048975846 hasConceptScore W2048975846C197341189 @default.
• W2048975846 hasConceptScore W2048975846C198399640 @default.
• W2048975846 hasConceptScore W2048975846C22885893 @default.
• W2048975846 hasConceptScore W2048975846C2775910092 @default.

• next