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- W2048981673 abstract "The mechanism for forming linear microtubule (MT) arrays in cells such as neurons, polarized epithelial cells, and myotubes is not well understood. A simpler bipolar linear array is the fission yeast interphase MT bundle, which in its basic form contains two MTs that are bundled at their minus ends. Here, we characterize mto2p as a novel fission yeast protein required for MT nucleation from noncentrosomal γ-tubulin complexes (γ-TuCs). In interphase mto2Δ cells, MT nucleation was strongly inhibited, and MT bundling occurred infrequently and only when two MTs met by chance in the cytoplasm. In wild-type 2, we observed MT nucleation from γ-TuCs bound along the length of existing MTs. We propose a model on how these nucleation events can more efficiently drive the formation of bipolar MT bundles in interphase. Key to the model is our observation of selective antiparallel binding of MTs, which can both explain the generation and spatial separation of multiple bipolar bundles." @default.
- W2048981673 created "2016-06-24" @default.
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- W2048981673 date "2005-04-18" @default.
- W2048981673 modified "2023-09-25" @default.
- W2048981673 title "Efficient formation of bipolar microtubule bundles requires microtubule-bound γ-tubulin complexes" @default.
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- W2048981673 doi "https://doi.org/10.1083/jcb.200410119" @default.
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