Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048986230> ?p ?o ?g. }
- W2048986230 endingPage "288" @default.
- W2048986230 startingPage "277" @default.
- W2048986230 abstract "Aim: To investigate the role of genetic polymorphisms in glutamatergic and GABAergic genes and their interactions with environmental stressors in antidepressant response. Methods: A set of 114 SNPs of 34 glutamatergic and GABAergic genes, mainly in promoter and coding regions, were genotyped in 281 Chinese Han major depressive disorder patients. The 17-item Hamilton Depression Rating Scale was used to evaluate the symptom severity and therapeutic efficacy. Childhood Trauma Questionnaire and Life Events Scale were used for assessing early-onset and recent stressful life events, respectively. Results: The single SNPs rs1954787 (GRIK4), rs1992647 (GABRA6), rs10036156 (GABRP) and rs3810651 (GABRQ) were significantly associated with antidepressant response, as were haplotypes in GRIK4 and GABRP genes. A genetic interaction between rs11542313 (GAD1), rs13303344 (GABRD) and rs2256882 (GABRE) was identified as impacting therapeutic response. SNPs in GRIA3 demonstrated interactions with early-onset adverse events and recent negative life stress that influence treatment outcome. Conclusion: Genetic polymorphisms in the glutamatergic and GABAergic systems and certain genetic interactions, as well as gene–environment interactions, are associated with antidepressant response. Original submitted 9 July 2012; Revision submitted 1 January 2013" @default.
- W2048986230 created "2016-06-24" @default.
- W2048986230 creator A5011540763 @default.
- W2048986230 creator A5017269298 @default.
- W2048986230 creator A5017958306 @default.
- W2048986230 creator A5032606916 @default.
- W2048986230 creator A5044901407 @default.
- W2048986230 creator A5049776440 @default.
- W2048986230 creator A5050988890 @default.
- W2048986230 creator A5075165718 @default.
- W2048986230 date "2013-02-01" @default.
- W2048986230 modified "2023-10-12" @default.
- W2048986230 title "Influence of genetic polymorphisms in the glutamatergic and GABAergic systems and their interactions with environmental stressors on antidepressant response" @default.
- W2048986230 cites W1966745635 @default.
- W2048986230 cites W1972297717 @default.
- W2048986230 cites W1976634586 @default.
- W2048986230 cites W1977874045 @default.
- W2048986230 cites W1983585786 @default.
- W2048986230 cites W1993251799 @default.
- W2048986230 cites W1993695011 @default.
- W2048986230 cites W1994950269 @default.
- W2048986230 cites W1996109785 @default.
- W2048986230 cites W1999081857 @default.
- W2048986230 cites W1999388555 @default.
- W2048986230 cites W2000388202 @default.
- W2048986230 cites W2001555806 @default.
- W2048986230 cites W2003470167 @default.
- W2048986230 cites W2007974392 @default.
- W2048986230 cites W2009336731 @default.
- W2048986230 cites W2009939501 @default.
- W2048986230 cites W2012199810 @default.
- W2048986230 cites W2017305294 @default.
- W2048986230 cites W2019182935 @default.
- W2048986230 cites W2020393851 @default.
- W2048986230 cites W2022549781 @default.
- W2048986230 cites W2022922036 @default.
- W2048986230 cites W2023866167 @default.
- W2048986230 cites W2033483393 @default.
- W2048986230 cites W2036951530 @default.
- W2048986230 cites W2046650821 @default.
- W2048986230 cites W2047897906 @default.
- W2048986230 cites W2049670655 @default.
- W2048986230 cites W2053928326 @default.
- W2048986230 cites W2056293062 @default.
- W2048986230 cites W2057823239 @default.
- W2048986230 cites W2057887105 @default.
- W2048986230 cites W2069228506 @default.
- W2048986230 cites W2070514336 @default.
- W2048986230 cites W2071709232 @default.
- W2048986230 cites W2076682630 @default.
- W2048986230 cites W2078870036 @default.
- W2048986230 cites W2079382397 @default.
- W2048986230 cites W2080245295 @default.
- W2048986230 cites W2080609824 @default.
- W2048986230 cites W2087467518 @default.
- W2048986230 cites W2090267398 @default.
- W2048986230 cites W2099120666 @default.
- W2048986230 cites W2109334244 @default.
- W2048986230 cites W2114906335 @default.
- W2048986230 cites W2116629441 @default.
- W2048986230 cites W2116733205 @default.
- W2048986230 cites W2116991563 @default.
- W2048986230 cites W2123738251 @default.
- W2048986230 cites W2147351691 @default.
- W2048986230 cites W2148830430 @default.
- W2048986230 cites W2162196924 @default.
- W2048986230 cites W2162633534 @default.
- W2048986230 cites W2316943902 @default.
- W2048986230 cites W2416116271 @default.
- W2048986230 cites W3164656276 @default.
- W2048986230 doi "https://doi.org/10.2217/pgs.13.1" @default.
- W2048986230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23394390" @default.
- W2048986230 hasPublicationYear "2013" @default.
- W2048986230 type Work @default.
- W2048986230 sameAs 2048986230 @default.
- W2048986230 citedByCount "43" @default.
- W2048986230 countsByYear W20489862302013 @default.
- W2048986230 countsByYear W20489862302014 @default.
- W2048986230 countsByYear W20489862302015 @default.
- W2048986230 countsByYear W20489862302016 @default.
- W2048986230 countsByYear W20489862302017 @default.
- W2048986230 countsByYear W20489862302018 @default.
- W2048986230 countsByYear W20489862302019 @default.
- W2048986230 countsByYear W20489862302020 @default.
- W2048986230 countsByYear W20489862302021 @default.
- W2048986230 countsByYear W20489862302022 @default.
- W2048986230 countsByYear W20489862302023 @default.
- W2048986230 crossrefType "journal-article" @default.
- W2048986230 hasAuthorship W2048986230A5011540763 @default.
- W2048986230 hasAuthorship W2048986230A5017269298 @default.
- W2048986230 hasAuthorship W2048986230A5017958306 @default.
- W2048986230 hasAuthorship W2048986230A5032606916 @default.
- W2048986230 hasAuthorship W2048986230A5044901407 @default.
- W2048986230 hasAuthorship W2048986230A5049776440 @default.
- W2048986230 hasAuthorship W2048986230A5050988890 @default.
- W2048986230 hasAuthorship W2048986230A5075165718 @default.
- W2048986230 hasConcept C104317684 @default.
- W2048986230 hasConcept C118552586 @default.