Matches in SemOpenAlex for { <https://semopenalex.org/work/W2048992261> ?p ?o ?g. }
- W2048992261 endingPage "2391" @default.
- W2048992261 startingPage "2383" @default.
- W2048992261 abstract "Glucocorticoids (GCs) are widely used anti-inflammatory agents that frequently induce side effects, including insulin resistance, diabetes and hypertension. Here, we investigated the contribution of microvascular dysfunction to the development of these adverse effects in healthy men.In a randomised, placebo-controlled, dose-response intervention study, 32 healthy normoglycaemic men (age: 21 ± 2 years; BMI: 21.9 ± 1.7 kg/m(2)) were allocated to receive prednisolone 30 mg once daily (n = 12), prednisolone 7.5 mg once daily (n = 12) or placebo (n = 8) for 2 weeks using block randomisation. A central office performed the treatment allocation, and medication was dispersed by the hospital pharmacy that was also blinded. Treatment allocation was kept in concealed envelopes. Participants, study personnel conducting the measures and assessing the outcome were blinded to group assignment. The study was conducted at a university hospital. Primary endpoint was prednisolone-induced changes in microvascular function, which was assessed by capillary microscopy. Insulin sensitivity was determined by hyperinsulinaemic-euglycaemic clamp and postprandial glycaemic excursions by standardised meal tests.Compared with placebo, prednisolone 7.5 mg and 30 mg decreased insulin-stimulated capillary recruitment by 9 ± 4% and 17 ± 3%, respectively (p < 0.01). In addition, prednisolone 7.5 mg and 30 mg reduced insulin sensitivity (M value) by -11.4 ± 4.5 μmol kg(-1) min(-1) and -25.1 ± 4.1 μmol kg(-1) min(-1) (p < 0.001) and increased postprandial glucose levels by 11 ± 5% and 27 ± 9% (p < 0.001), respectively. Only high-dose prednisolone increased systolic blood pressure (6 ± 1.2 mmHg, p = 0.006). Prednisolone-induced changes in insulin-stimulated capillary recruitment were associated with insulin sensitivity (r = +0.76; p < 0.001), postprandial glucose concentrations (r = -0.52; p < 0.03) and systolic blood pressure (r = -0.62; p < 0.001). Prednisolone increased resistin concentrations, which were negatively related to insulin-stimulated capillary recruitment (r = -0.40; p = 0.03). No effects were noted on adiponectin and leptin concentrations. Prednisolone treatment was well tolerated; none of the participants left the study.Prednisolone-induced impairment of insulin-stimulated capillary recruitment was paralleled by insulin resistance, increased postprandial glucose levels, hypertension and increased circulating resistin concentrations in healthy men. We propose that GC-induced impairments of microvascular function may contribute to the adverse effects of GC treatment on glucose metabolism and blood pressure.isrctn.org ISRTCN 78149983.The study was funded by the Dutch Top Institute Pharma T1-106." @default.
- W2048992261 created "2016-06-24" @default.
- W2048992261 creator A5000013385 @default.
- W2048992261 creator A5025621864 @default.
- W2048992261 creator A5025693848 @default.
- W2048992261 creator A5029349104 @default.
- W2048992261 creator A5035147756 @default.
- W2048992261 creator A5067127165 @default.
- W2048992261 creator A5068474395 @default.
- W2048992261 creator A5075327554 @default.
- W2048992261 date "2013-08-11" @default.
- W2048992261 modified "2023-09-27" @default.
- W2048992261 title "Glucocorticoid treatment impairs microvascular function in healthy men in association with its adverse effects on glucose metabolism and blood pressure: a randomised controlled trial" @default.
- W2048992261 cites W1964478477 @default.
- W2048992261 cites W1972190403 @default.
- W2048992261 cites W1974022347 @default.
- W2048992261 cites W1978030502 @default.
- W2048992261 cites W1981004008 @default.
- W2048992261 cites W1997103341 @default.
- W2048992261 cites W2014887370 @default.
- W2048992261 cites W2033746638 @default.
- W2048992261 cites W2057624928 @default.
- W2048992261 cites W2066854299 @default.
- W2048992261 cites W2093214567 @default.
- W2048992261 cites W2094661308 @default.
- W2048992261 cites W2097143249 @default.
- W2048992261 cites W2099276421 @default.
- W2048992261 cites W2104372526 @default.
- W2048992261 cites W2105803008 @default.
- W2048992261 cites W2109018676 @default.
- W2048992261 cites W2114412338 @default.
- W2048992261 cites W2114633474 @default.
- W2048992261 cites W2116420100 @default.
- W2048992261 cites W2120107821 @default.
- W2048992261 cites W2120890763 @default.
- W2048992261 cites W2124343304 @default.
- W2048992261 cites W2126412451 @default.
- W2048992261 cites W2127277443 @default.
- W2048992261 cites W2133465800 @default.
- W2048992261 cites W2144626540 @default.
- W2048992261 cites W2150429576 @default.
- W2048992261 cites W2166073051 @default.
- W2048992261 cites W2166260890 @default.
- W2048992261 cites W2170401329 @default.
- W2048992261 cites W2171303876 @default.
- W2048992261 cites W4242583868 @default.
- W2048992261 doi "https://doi.org/10.1007/s00125-013-3016-8" @default.
- W2048992261 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23933953" @default.
- W2048992261 hasPublicationYear "2013" @default.
- W2048992261 type Work @default.
- W2048992261 sameAs 2048992261 @default.
- W2048992261 citedByCount "24" @default.
- W2048992261 countsByYear W20489922612014 @default.
- W2048992261 countsByYear W20489922612015 @default.
- W2048992261 countsByYear W20489922612016 @default.
- W2048992261 countsByYear W20489922612017 @default.
- W2048992261 countsByYear W20489922612018 @default.
- W2048992261 countsByYear W20489922612019 @default.
- W2048992261 countsByYear W20489922612020 @default.
- W2048992261 countsByYear W20489922612021 @default.
- W2048992261 countsByYear W20489922612022 @default.
- W2048992261 crossrefType "journal-article" @default.
- W2048992261 hasAuthorship W2048992261A5000013385 @default.
- W2048992261 hasAuthorship W2048992261A5025621864 @default.
- W2048992261 hasAuthorship W2048992261A5025693848 @default.
- W2048992261 hasAuthorship W2048992261A5029349104 @default.
- W2048992261 hasAuthorship W2048992261A5035147756 @default.
- W2048992261 hasAuthorship W2048992261A5067127165 @default.
- W2048992261 hasAuthorship W2048992261A5068474395 @default.
- W2048992261 hasAuthorship W2048992261A5075327554 @default.
- W2048992261 hasBestOaLocation W20489922611 @default.
- W2048992261 hasConcept C126322002 @default.
- W2048992261 hasConcept C134018914 @default.
- W2048992261 hasConcept C142724271 @default.
- W2048992261 hasConcept C197934379 @default.
- W2048992261 hasConcept C204787440 @default.
- W2048992261 hasConcept C27081682 @default.
- W2048992261 hasConcept C2776715498 @default.
- W2048992261 hasConcept C2777391703 @default.
- W2048992261 hasConcept C2778199505 @default.
- W2048992261 hasConcept C2779306644 @default.
- W2048992261 hasConcept C2780841215 @default.
- W2048992261 hasConcept C555293320 @default.
- W2048992261 hasConcept C71924100 @default.
- W2048992261 hasConcept C84393581 @default.
- W2048992261 hasConceptScore W2048992261C126322002 @default.
- W2048992261 hasConceptScore W2048992261C134018914 @default.
- W2048992261 hasConceptScore W2048992261C142724271 @default.
- W2048992261 hasConceptScore W2048992261C197934379 @default.
- W2048992261 hasConceptScore W2048992261C204787440 @default.
- W2048992261 hasConceptScore W2048992261C27081682 @default.
- W2048992261 hasConceptScore W2048992261C2776715498 @default.
- W2048992261 hasConceptScore W2048992261C2777391703 @default.
- W2048992261 hasConceptScore W2048992261C2778199505 @default.
- W2048992261 hasConceptScore W2048992261C2779306644 @default.
- W2048992261 hasConceptScore W2048992261C2780841215 @default.
- W2048992261 hasConceptScore W2048992261C555293320 @default.
- W2048992261 hasConceptScore W2048992261C71924100 @default.