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• W2049020791 abstract "The normal values for the plasma concentration, excretion and twenty-four hour endogenous clearance of creatinine are given. Thirty men and thirty women were studied and in fifteen of each sex, measurements of both creatinine and true creatinine in the plasma were made. The non-creatinine chromogen did not influence the variability of the plasma values within a single individual or among a group of individuals. Correlation analyses revealed that the sex difference in plasma concentration and clearance could be removed by correcting for lean body weight. In ten additional subjects, there was no difference in one hour clearance values measured in the morning and afternoon, but these values did exceed the twenty-four hour values by some 7 to 11 per cent. In eighty patients with evidence of renal disease, it was found that if the plasma creatinine was less than . in men and less than . in women, the clearance value is normal unless the patient has extensive muscular wasting. If the plasma concentration is 1.25 to . in men or 1.1 to . in women, the clearance may vary from definitely low to normal values. With values greater than . in men and . in women, the clearance is always low. Comparable relationships exist with true creatinine measurements. It is concluded that clearance measurements should be made and reliance not placed on the value predicted from the concentration of true creatinine in the plasma. The variability of the values in patients with evidence of renal disease was no greater for creatinine than for true creatinine measurements, and the information provided with each method was in close agreement. Either method is suitable for clinical purposes but a preference is expressed for true creatinine measurements if the plasma values are low normal or less. It is concluded that restrictive measures designed to minimize the variability resulting from changes in diet and the amount of physical activity are not justified. Similarly, corrections for surface area and lean body weight improve the normal values but are of limited usefulness in patients with evidence of renal disease. Creatinine formation in the body is briefly reviewed and instances of diminished production are commented on. Although clearance measurements offer the best means of detecting definite impairment of renal excretory function, the wide range of normal values limits the usefulness of such measurements in detecting lesser amounts of renal damage. Particular emphasis is therefore placed on the value of serial determinations in uncovering early renal impairment and in evaluating borderline values as well as the patient's prognosis and the influence of therapy. The opinion is expressed that one hour clearance measurements provide information as useful as that obtained when twenty-four hour urine collections are used." @default.
• W2049020791 created "2016-06-24" @default.
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• W2049020791 date "1962-01-01" @default.
• W2049020791 modified "2023-10-18" @default.
• W2049020791 title "A clinical appraisal of the plasma concentration and endogenous clearance of creatinine" @default.
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• W2049020791 doi "https://doi.org/10.1016/0002-9343(62)90183-3" @default.
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