FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049024458> ?p ?o ?g. }

• W2049024458 endingPage "396" @default.
• W2049024458 startingPage "387" @default.
• W2049024458 abstract "The aim of this study was to determine whether culture-conditioned medium (CCM) can prevent neuronal damage caused by excitotoxicity or by chemical ischemia in cultured chick retina cells. Excitotoxic conditions were obtained by incubating retina cells with glutamate or kainate and chemical ischemia was induced by metabolic inhibition. In this case, cultures were briefly exposed to sodium cyanide, to block oxidative phosphorylation and iodoacetic acid, to block glycolysis. The assessment of neuronal injury was made spectrophotometrically by quantification of cellularly reduced MTT. Stimulation of retina cells with glutamate or kainate in serum deprived culture medium (BME-FCS), lead to a decrease in the MTT metabolism that was dependent on the time of exposure to the toxic agents. CCM prevented cell damage, either when present during the stimulation period or during the recovery period. This protection was more prominent in the case of kainate-induced neuronal death. Chemical ischemia also lead to a decrease of the MTT metabolism in a time-dependent manner and CCM protected retina cells from ischemia-induced lesions when present during the stimulation period and during the recovery period. The protective effect of CCM was partially decreased by the tyrosine kinase inhibitor, genistein, when the cells were stimulated with kainate, but not with glutamate, or when the cells were subjected to chemical ischemia. CCM protected retina cells against both the acute and the delayed toxicity induced by either glutamate or kainate, or by chemical ischemia, when present during both the insult and the recovery period. The presence of survival factors in the media may effectively inhibit the cell death signals generated by glutamate receptor activation or by chemical ischemia." @default.
• W2049024458 created "2016-06-24" @default.
• W2049024458 creator A5012338889 @default.
• W2049024458 creator A5053721388 @default.
• W2049024458 creator A5070373037 @default.
• W2049024458 creator A5076323554 @default.
• W2049024458 date "1998-04-01" @default.
• W2049024458 modified "2023-09-27" @default.
• W2049024458 title "Culture medium components modulate retina cell damage induced by glutamate, kainate or “chemical ischemia”" @default.
• W2049024458 cites W1551662804 @default.
• W2049024458 cites W1595132023 @default.
• W2049024458 cites W1639407471 @default.
• W2049024458 cites W1656644300 @default.
• W2049024458 cites W1890775238 @default.
• W2049024458 cites W1920015810 @default.
• W2049024458 cites W1968267810 @default.
• W2049024458 cites W1969809933 @default.
• W2049024458 cites W1975164567 @default.
• W2049024458 cites W1976140941 @default.
• W2049024458 cites W1979406476 @default.
• W2049024458 cites W1983179971 @default.
• W2049024458 cites W1984872319 @default.
• W2049024458 cites W1994414897 @default.
• W2049024458 cites W1996568613 @default.
• W2049024458 cites W1997772006 @default.
• W2049024458 cites W2001620293 @default.
• W2049024458 cites W2004469687 @default.
• W2049024458 cites W2006904109 @default.
• W2049024458 cites W2011527331 @default.
• W2049024458 cites W2016293448 @default.
• W2049024458 cites W2017522921 @default.
• W2049024458 cites W2019520319 @default.
• W2049024458 cites W2022433901 @default.
• W2049024458 cites W2022797477 @default.
• W2049024458 cites W2023319572 @default.
• W2049024458 cites W2023624766 @default.
• W2049024458 cites W2028685800 @default.
• W2049024458 cites W2033027472 @default.
• W2049024458 cites W2033740616 @default.
• W2049024458 cites W2040983591 @default.
• W2049024458 cites W2045807655 @default.
• W2049024458 cites W2057112721 @default.
• W2049024458 cites W2059085681 @default.
• W2049024458 cites W2060344266 @default.
• W2049024458 cites W2062051253 @default.
• W2049024458 cites W2064837541 @default.
• W2049024458 cites W2068383018 @default.
• W2049024458 cites W2073014630 @default.
• W2049024458 cites W2074572230 @default.
• W2049024458 cites W2076424472 @default.
• W2049024458 cites W2084022990 @default.
• W2049024458 cites W2085361929 @default.
• W2049024458 cites W2092444029 @default.
• W2049024458 cites W2094247127 @default.
• W2049024458 cites W2099161484 @default.
• W2049024458 cites W2101298801 @default.
• W2049024458 cites W2103105379 @default.
• W2049024458 cites W2110551570 @default.
• W2049024458 cites W2114918609 @default.
• W2049024458 cites W2115379144 @default.
• W2049024458 cites W2124077248 @default.
• W2049024458 cites W2125403403 @default.
• W2049024458 cites W2133496097 @default.
• W2049024458 cites W2147938955 @default.
• W2049024458 cites W2149949743 @default.
• W2049024458 cites W2152985670 @default.
• W2049024458 cites W2157360196 @default.
• W2049024458 cites W4233005545 @default.
• W2049024458 cites W4298150824 @default.
• W2049024458 doi "https://doi.org/10.1016/s0197-0186(97)00099-5" @default.
• W2049024458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9596563" @default.
• W2049024458 hasPublicationYear "1998" @default.
• W2049024458 type Work @default.
• W2049024458 sameAs 2049024458 @default.
• W2049024458 citedByCount "11" @default.
• W2049024458 countsByYear W20490244582015 @default.
• W2049024458 crossrefType "journal-article" @default.
• W2049024458 hasAuthorship W2049024458A5012338889 @default.
• W2049024458 hasAuthorship W2049024458A5053721388 @default.
• W2049024458 hasAuthorship W2049024458A5070373037 @default.
• W2049024458 hasAuthorship W2049024458A5076323554 @default.
• W2049024458 hasConcept C126322002 @default.
• W2049024458 hasConcept C134018914 @default.
• W2049024458 hasConcept C160268369 @default.
• W2049024458 hasConcept C169760540 @default.
• W2049024458 hasConcept C170493617 @default.
• W2049024458 hasConcept C185592680 @default.
• W2049024458 hasConcept C189184402 @default.
• W2049024458 hasConcept C24998067 @default.
• W2049024458 hasConcept C2776108384 @default.
• W2049024458 hasConcept C2777093970 @default.
• W2049024458 hasConcept C2781012912 @default.
• W2049024458 hasConcept C541997718 @default.
• W2049024458 hasConcept C55493867 @default.
• W2049024458 hasConcept C61174792 @default.
• W2049024458 hasConcept C71924100 @default.
• W2049024458 hasConcept C86803240 @default.
• W2049024458 hasConcept C98274493 @default.

• next