FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049025878> ?p ?o ?g. }

• W2049025878 endingPage "1518" @default.
• W2049025878 startingPage "1508" @default.
• W2049025878 abstract "Although minimal model analysis of frequently sampled iv glucose tolerance tests (FSIGTs) to measure insulin sensitivity is well recognized, application has been limited by the need for endogenous insulin secretion. In the present study we determined whether use of exogenous insulin could permit minimal model assessment of insulin sensitivity (S1) to be extended to diabetic subjects. Normal volunteers had separate FSIGT assessments supplemented with both tolbutamide and insulin to accelerate glucose disappearance, while diabetics had a FSIGT supplemented only with insulin. There was a strong and highly significant correlation between the two assessments in normal subjects (r = 0.87; P < 0.001), and the rank order of S1 generally was maintained with the two assessments over a 3–fold range of S1; however, insulin-determined S1 was 16% lower (3.4 ± 0.4 vs. 4.1 ± 0.4 × 10–4 min/μU-mL; P < 0.01). Diabetic subjects had markedly lower insulin sensitivity than controls (S1 = 0.61 ± 0.16; P < 0.0001). Across all subjects, the level of fasting serum glucose was correlated inversely with both insulin sensitivity (r = –0.62; P < 0.05) and acute insulin responses (r = –0.72; P < 0.02); however, insulin sensitivity in diabetic subjects with little insulin secretion (0.6 ± 0.2) was comparable to insulin sensitivity in diabetic subjects with near-normal responses (0.6 ± 0.3). In subjects with fasting hyperglycemia, there were significant correlations between insulin sensitivity and body mass index, percent fat mass, and waist/hip ratio (all P < 0.03). Among all female subjects, there was also a strong correlation between insulin sensitivity and upper body obesity, as measured by waist/hip ratio (r = –0.68; P < 0.02). Model parameters also permitted glucose uptake to be estimated in diabetic vs. normal subjects at comparable hyperglycemia (11.1 mmol/L). Total glucose uptake was decreased in diabetic subjects (5.2 ± 0.8 us. 12.7 ± 1.7 mg/min-kg in normals; P < 0.001), insulin-dependent glucose uptake was diminished to a greater extent (1.3 ± 0.4 vs. 6.2 ± 1.2) than noninsulin-independent glucose uptake (3.9 ± 0.5 vs. 6.4 ± 0.9; both P < 0.02). Administration of insulin permits minimal model FSIGT analysis to be applied to diabetic as well as normal subjects, yielding information about both insulin- and noninsulin-mediated glucose uptake as well as insulin sensitivity and insulin secretion." @default.
• W2049025878 created "2016-06-24" @default.
• W2049025878 creator A5024971327 @default.
• W2049025878 creator A5030791389 @default.
• W2049025878 creator A5061795428 @default.
• W2049025878 creator A5089293388 @default.
• W2049025878 date "1990-12-01" @default.
• W2049025878 modified "2023-10-15" @default.
• W2049025878 title "Minimal Model Analysis of Intravenous Glucose Tolerance Test-Derived Insulin Sensitivity in Diabetic Subjects*" @default.
• W2049025878 cites W1844367202 @default.
• W2049025878 cites W1860443407 @default.
• W2049025878 cites W1970783645 @default.
• W2049025878 cites W1972324814 @default.
• W2049025878 cites W1974127796 @default.
• W2049025878 cites W1974363442 @default.
• W2049025878 cites W1974540301 @default.
• W2049025878 cites W1977797609 @default.
• W2049025878 cites W1984153001 @default.
• W2049025878 cites W2028823035 @default.
• W2049025878 cites W2031820400 @default.
• W2049025878 cites W2033125833 @default.
• W2049025878 cites W2040124635 @default.
• W2049025878 cites W2060593308 @default.
• W2049025878 cites W2078073869 @default.
• W2049025878 cites W2092535457 @default.
• W2049025878 cites W2098578065 @default.
• W2049025878 cites W2113413704 @default.
• W2049025878 cites W2125624587 @default.
• W2049025878 cites W2127283734 @default.
• W2049025878 cites W2129810295 @default.
• W2049025878 cites W2130171861 @default.
• W2049025878 cites W2131984640 @default.
• W2049025878 cites W2134164993 @default.
• W2049025878 cites W2140125216 @default.
• W2049025878 cites W2142025433 @default.
• W2049025878 cites W2149860530 @default.
• W2049025878 cites W2156353972 @default.
• W2049025878 cites W2161503212 @default.
• W2049025878 cites W2164519184 @default.
• W2049025878 cites W2168588540 @default.
• W2049025878 cites W2406299273 @default.
• W2049025878 cites W2410318725 @default.
• W2049025878 cites W2416054406 @default.
• W2049025878 cites W2418580865 @default.
• W2049025878 cites W74713816 @default.
• W2049025878 cites W2316423620 @default.
• W2049025878 doi "https://doi.org/10.1210/jcem-71-6-1508" @default.
• W2049025878 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2229309" @default.
• W2049025878 hasPublicationYear "1990" @default.
• W2049025878 type Work @default.
• W2049025878 sameAs 2049025878 @default.
• W2049025878 citedByCount "325" @default.
• W2049025878 countsByYear W20490258782012 @default.
• W2049025878 countsByYear W20490258782013 @default.
• W2049025878 countsByYear W20490258782014 @default.
• W2049025878 countsByYear W20490258782015 @default.
• W2049025878 countsByYear W20490258782016 @default.
• W2049025878 countsByYear W20490258782017 @default.
• W2049025878 countsByYear W20490258782018 @default.
• W2049025878 countsByYear W20490258782019 @default.
• W2049025878 countsByYear W20490258782020 @default.
• W2049025878 countsByYear W20490258782021 @default.
• W2049025878 countsByYear W20490258782022 @default.
• W2049025878 countsByYear W20490258782023 @default.
• W2049025878 crossrefType "journal-article" @default.
• W2049025878 hasAuthorship W2049025878A5024971327 @default.
• W2049025878 hasAuthorship W2049025878A5030791389 @default.
• W2049025878 hasAuthorship W2049025878A5061795428 @default.
• W2049025878 hasAuthorship W2049025878A5089293388 @default.
• W2049025878 hasConcept C126322002 @default.
• W2049025878 hasConcept C134018914 @default.
• W2049025878 hasConcept C2776054734 @default.
• W2049025878 hasConcept C2777180221 @default.
• W2049025878 hasConcept C2777391703 @default.
• W2049025878 hasConcept C2779306644 @default.
• W2049025878 hasConcept C2780221984 @default.
• W2049025878 hasConcept C2780352109 @default.
• W2049025878 hasConcept C2780833929 @default.
• W2049025878 hasConcept C3017594256 @default.
• W2049025878 hasConcept C555293320 @default.
• W2049025878 hasConcept C71924100 @default.
• W2049025878 hasConceptScore W2049025878C126322002 @default.
• W2049025878 hasConceptScore W2049025878C134018914 @default.
• W2049025878 hasConceptScore W2049025878C2776054734 @default.
• W2049025878 hasConceptScore W2049025878C2777180221 @default.
• W2049025878 hasConceptScore W2049025878C2777391703 @default.
• W2049025878 hasConceptScore W2049025878C2779306644 @default.
• W2049025878 hasConceptScore W2049025878C2780221984 @default.
• W2049025878 hasConceptScore W2049025878C2780352109 @default.
• W2049025878 hasConceptScore W2049025878C2780833929 @default.
• W2049025878 hasConceptScore W2049025878C3017594256 @default.
• W2049025878 hasConceptScore W2049025878C555293320 @default.
• W2049025878 hasConceptScore W2049025878C71924100 @default.
• W2049025878 hasIssue "6" @default.
• W2049025878 hasLocation W20490258781 @default.
• W2049025878 hasLocation W20490258782 @default.
• W2049025878 hasOpenAccess W2049025878 @default.
• W2049025878 hasPrimaryLocation W20490258781 @default.

• next