FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049056009> ?p ?o ?g. }

• W2049056009 endingPage "848" @default.
• W2049056009 startingPage "841" @default.
• W2049056009 abstract "Serum sFas and p53 protein have been observed in breast cancer patients, but their clinical usefulness for diagnosis and therapy monitoring has not been clarified. The aim of this study was to compare the clinical utility of serum sFas and p53 protein with that of serum CA 15-3 as the most commonly used breast cancer tumor marker. Serum samples were taken from 35 normal healthy controls and 35 breast cancer patients before surgery, after 2 weeks of surgery and after six cycles of FAC chemotherapy. Serum sFas and p53 protein levels were measured using ELISA kits. Serum CA 15-3 levels were determined using IRMA kit. Mean Serum levels of sFas and CA 15-3 were significantly elevated while p53 protein was significantly declined in breast cancer patients than controls. Serum p53 protein showed the greatest significant area under the ROC curve (84.3%) followed by sFas (80.5%), then CA 15-3 (78%). The sensitivity, specificity and cut-off value for diagnosing breast cancer patients were 84.2%, 82.6% and 2.88 U/ml for p53 protein, 83.3%, 68.2% and 497.3 pg/ml for sFas and 45.8%, 100% and 23 U/ml for CA15-3. Surgical removal of breast resulted in a significant decline in serum sFas level with no effect on serum p53 protein and CA 15-3 levels. Six cycles of chemotherapy resulted in a significant elevation in serum sFas level with no effect on serum p53 protein and CA 15-3 levels. sFas was significantly correlated with tumor grade. It could be concluded that although serum p53 protein is superior to sFas and CA15-3 for diagnosis of breast cancer patients, only sFas is useful for monitoring the response of breast cancer patients to surgery and chemotherapy if the effect of systemic inflammatory reactions is excluded." @default.
• W2049056009 created "2016-06-24" @default.
• W2049056009 creator A5038347453 @default.
• W2049056009 creator A5038595138 @default.
• W2049056009 creator A5069290608 @default.
• W2049056009 creator A5072535940 @default.
• W2049056009 date "2012-03-17" @default.
• W2049056009 modified "2023-09-27" @default.
• W2049056009 title "The Clinical Significance of Serum Soluble Fas and p53 Protein in Breast Cancer Patients: Comparison with Serum CA 15-3" @default.
• W2049056009 cites W199014718 @default.
• W2049056009 cites W2008015379 @default.
• W2049056009 cites W2024933893 @default.
• W2049056009 cites W2033878064 @default.
• W2049056009 cites W2045082964 @default.
• W2049056009 cites W2057811319 @default.
• W2049056009 cites W2066527330 @default.
• W2049056009 cites W2093081470 @default.
• W2049056009 cites W2094776056 @default.
• W2049056009 cites W2101909316 @default.
• W2049056009 cites W2104384388 @default.
• W2049056009 cites W2121526560 @default.
• W2049056009 cites W2168084973 @default.
• W2049056009 cites W2168884559 @default.
• W2049056009 cites W2170481258 @default.
• W2049056009 cites W2327637664 @default.
• W2049056009 doi "https://doi.org/10.1007/s12253-012-9512-1" @default.
• W2049056009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22422199" @default.
• W2049056009 hasPublicationYear "2012" @default.
• W2049056009 type Work @default.
• W2049056009 sameAs 2049056009 @default.
• W2049056009 citedByCount "8" @default.
• W2049056009 countsByYear W20490560092013 @default.
• W2049056009 countsByYear W20490560092014 @default.
• W2049056009 countsByYear W20490560092015 @default.
• W2049056009 countsByYear W20490560092017 @default.
• W2049056009 countsByYear W20490560092021 @default.
• W2049056009 crossrefType "journal-article" @default.
• W2049056009 hasAuthorship W2049056009A5038347453 @default.
• W2049056009 hasAuthorship W2049056009A5038595138 @default.
• W2049056009 hasAuthorship W2049056009A5069290608 @default.
• W2049056009 hasAuthorship W2049056009A5072535940 @default.
• W2049056009 hasConcept C111683008 @default.
• W2049056009 hasConcept C118646709 @default.
• W2049056009 hasConcept C121608353 @default.
• W2049056009 hasConcept C126322002 @default.
• W2049056009 hasConcept C2776694085 @default.
• W2049056009 hasConcept C2781447364 @default.
• W2049056009 hasConcept C530470458 @default.
• W2049056009 hasConcept C71924100 @default.
• W2049056009 hasConcept C90924648 @default.
• W2049056009 hasConceptScore W2049056009C111683008 @default.
• W2049056009 hasConceptScore W2049056009C118646709 @default.
• W2049056009 hasConceptScore W2049056009C121608353 @default.
• W2049056009 hasConceptScore W2049056009C126322002 @default.
• W2049056009 hasConceptScore W2049056009C2776694085 @default.
• W2049056009 hasConceptScore W2049056009C2781447364 @default.
• W2049056009 hasConceptScore W2049056009C530470458 @default.
• W2049056009 hasConceptScore W2049056009C71924100 @default.
• W2049056009 hasConceptScore W2049056009C90924648 @default.
• W2049056009 hasIssue "4" @default.
• W2049056009 hasLocation W20490560091 @default.
• W2049056009 hasLocation W20490560092 @default.
• W2049056009 hasOpenAccess W2049056009 @default.
• W2049056009 hasPrimaryLocation W20490560091 @default.
• W2049056009 hasRelatedWork W1592909740 @default.
• W2049056009 hasRelatedWork W1973234915 @default.
• W2049056009 hasRelatedWork W2139425553 @default.
• W2049056009 hasRelatedWork W2144567703 @default.
• W2049056009 hasRelatedWork W2353143300 @default.
• W2049056009 hasRelatedWork W2399536800 @default.
• W2049056009 hasRelatedWork W2414383224 @default.
• W2049056009 hasRelatedWork W2415509534 @default.
• W2049056009 hasRelatedWork W3191765869 @default.
• W2049056009 hasRelatedWork W2801793452 @default.
• W2049056009 hasVolume "18" @default.
• W2049056009 isParatext "false" @default.
• W2049056009 isRetracted "false" @default.
• W2049056009 magId "2049056009" @default.
• W2049056009 workType "article" @default.