Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049060336> ?p ?o ?g. }
- W2049060336 endingPage "556" @default.
- W2049060336 startingPage "552" @default.
- W2049060336 abstract "Flavoproteins catalyse a diversity of fundamental redox reactions and are one of the most studied enzyme families. As monooxygenases, they are universally thought to control oxygenation by means of a peroxyflavin species that transfers a single atom of molecular oxygen to an organic substrate. Here we report that the bacterial flavoenzyme EncM catalyses the peroxyflavin-independent oxygenation-dehydrogenation dual oxidation of a highly reactive poly(β-carbonyl). The crystal structure of EncM with bound substrate mimics and isotope labelling studies reveal previously unknown flavin redox biochemistry. We show that EncM maintains an unexpected stable flavin-oxygenating species, proposed to be a flavin-N5-oxide, to promote substrate oxidation and trigger a rare Favorskii-type rearrangement that is central to the biosynthesis of the antibiotic enterocin. This work provides new insight into the fine-tuning of the flavin cofactor in offsetting the innate reactivity of a polyketide substrate to direct its efficient electrocyclization." @default.
- W2049060336 created "2016-06-24" @default.
- W2049060336 creator A5038121407 @default.
- W2049060336 creator A5039017104 @default.
- W2049060336 creator A5042160264 @default.
- W2049060336 creator A5051379973 @default.
- W2049060336 creator A5055103631 @default.
- W2049060336 creator A5055471333 @default.
- W2049060336 creator A5063765172 @default.
- W2049060336 creator A5080062473 @default.
- W2049060336 creator A5082491031 @default.
- W2049060336 date "2013-10-27" @default.
- W2049060336 modified "2023-10-09" @default.
- W2049060336 title "Flavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangement" @default.
- W2049060336 cites W103191813 @default.
- W2049060336 cites W1539796472 @default.
- W2049060336 cites W1554198147 @default.
- W2049060336 cites W1972963780 @default.
- W2049060336 cites W1973009377 @default.
- W2049060336 cites W1973270418 @default.
- W2049060336 cites W1974438278 @default.
- W2049060336 cites W1978775660 @default.
- W2049060336 cites W1984045227 @default.
- W2049060336 cites W1992557878 @default.
- W2049060336 cites W1994912497 @default.
- W2049060336 cites W1998369828 @default.
- W2049060336 cites W2000962149 @default.
- W2049060336 cites W2013718446 @default.
- W2049060336 cites W2015642465 @default.
- W2049060336 cites W2026654673 @default.
- W2049060336 cites W2026697320 @default.
- W2049060336 cites W2033330355 @default.
- W2049060336 cites W2037150792 @default.
- W2049060336 cites W2038840577 @default.
- W2049060336 cites W2042055680 @default.
- W2049060336 cites W2052577954 @default.
- W2049060336 cites W2059106160 @default.
- W2049060336 cites W2062455132 @default.
- W2049060336 cites W2063212143 @default.
- W2049060336 cites W2066128776 @default.
- W2049060336 cites W2070748794 @default.
- W2049060336 cites W2083090379 @default.
- W2049060336 cites W2087443330 @default.
- W2049060336 cites W2130775475 @default.
- W2049060336 cites W2137682340 @default.
- W2049060336 cites W2144081223 @default.
- W2049060336 cites W2146080841 @default.
- W2049060336 cites W2152301430 @default.
- W2049060336 cites W2153255725 @default.
- W2049060336 cites W2155028909 @default.
- W2049060336 cites W2166770813 @default.
- W2049060336 cites W2180229411 @default.
- W2049060336 doi "https://doi.org/10.1038/nature12643" @default.
- W2049060336 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3844076" @default.
- W2049060336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24162851" @default.
- W2049060336 hasPublicationYear "2013" @default.
- W2049060336 type Work @default.
- W2049060336 sameAs 2049060336 @default.
- W2049060336 citedByCount "133" @default.
- W2049060336 countsByYear W20490603362014 @default.
- W2049060336 countsByYear W20490603362015 @default.
- W2049060336 countsByYear W20490603362016 @default.
- W2049060336 countsByYear W20490603362017 @default.
- W2049060336 countsByYear W20490603362018 @default.
- W2049060336 countsByYear W20490603362019 @default.
- W2049060336 countsByYear W20490603362020 @default.
- W2049060336 countsByYear W20490603362021 @default.
- W2049060336 countsByYear W20490603362022 @default.
- W2049060336 countsByYear W20490603362023 @default.
- W2049060336 crossrefType "journal-article" @default.
- W2049060336 hasAuthorship W2049060336A5038121407 @default.
- W2049060336 hasAuthorship W2049060336A5039017104 @default.
- W2049060336 hasAuthorship W2049060336A5042160264 @default.
- W2049060336 hasAuthorship W2049060336A5051379973 @default.
- W2049060336 hasAuthorship W2049060336A5055103631 @default.
- W2049060336 hasAuthorship W2049060336A5055471333 @default.
- W2049060336 hasAuthorship W2049060336A5063765172 @default.
- W2049060336 hasAuthorship W2049060336A5080062473 @default.
- W2049060336 hasAuthorship W2049060336A5082491031 @default.
- W2049060336 hasBestOaLocation W20490603362 @default.
- W2049060336 hasConcept C13002179 @default.
- W2049060336 hasConcept C142724271 @default.
- W2049060336 hasConcept C178790620 @default.
- W2049060336 hasConcept C181199279 @default.
- W2049060336 hasConcept C185592680 @default.
- W2049060336 hasConcept C18903297 @default.
- W2049060336 hasConcept C197957613 @default.
- W2049060336 hasConcept C204787440 @default.
- W2049060336 hasConcept C21951064 @default.
- W2049060336 hasConcept C2776910235 @default.
- W2049060336 hasConcept C2777289219 @default.
- W2049060336 hasConcept C33093398 @default.
- W2049060336 hasConcept C526171541 @default.
- W2049060336 hasConcept C553450214 @default.
- W2049060336 hasConcept C55493867 @default.
- W2049060336 hasConcept C55904794 @default.
- W2049060336 hasConcept C71240020 @default.
- W2049060336 hasConcept C71924100 @default.