FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049064718> ?p ?o ?g. }

• W2049064718 endingPage "2536" @default.
• W2049064718 startingPage "2529" @default.
• W2049064718 abstract "Summary. Background: Elevated oxidized low-density lipoprotein (oxLDL) is associated with atherosclerosis and high cardiovascular risk. Previously, we identified 18 genes in coronary plaque macrophages of hypercholesterolemic pigs that correlated with plaque oxLDL. Objective: To determine which of these genes were differentially expressed in blood monocytes and correlated with blood and plaque oxLDL and with plaque complexity. Methods: RNA expression in monocytes of 27 hypercholesterolemic and 12 control pigs was analyzed with quantitative real-time polymerase chain reaction. Results: Five of 12 genes with detectable expression in monocytes were overexpressed (at P < 0.01 level) in blood monocytes of hypercholesterolemic pigs: ABCA1, SCD, IRF1, SDC2, and TLR2. ABCA1 RNA expression in blood monocytes correlated with blood oxLDL, and its RNA and protein expression was increased prior to atherosclerotic plaque formation. Higher expression of ABCA1 in monocytes was associated with higher plaque complexity and higher plaque oxLDL. Immunostaining of coronary plaques showed the association of ABCA1 with macrophages, lipids, and oxLDL; ABCA1 protein correlated with plaque oxLDL (R2 = 0.66; P < 0.0001). In THP-1 monocytes, oxLDL induced ABCA1 expression. OxLDL-induced foam cell generation in THP-1 and human monocyte-derived macrophages was associated with a further increase of ABCA1 expression. Conclusions: The increase of ABCA1 in monocytes in association with blood oxLDL prior to atherosclerotic lesion formation and the association of higher ABCA1 with higher plaque complexity suggests that ABCA1 is an early biomarker of atherosclerosis. Studies in humans are warranted." @default.
• W2049064718 created "2016-06-24" @default.
• W2049064718 creator A5007259656 @default.
• W2049064718 creator A5020839507 @default.
• W2049064718 creator A5026981224 @default.
• W2049064718 creator A5055695135 @default.
• W2049064718 creator A5062095347 @default.
• W2049064718 creator A5075714080 @default.
• W2049064718 date "2007-12-01" @default.
• W2049064718 modified "2023-09-27" @default.
• W2049064718 title "Oxidized low‐density lipoprotein‐induced expression of ABCA1 in blood monocytes precedes coronary atherosclerosis and is associated with plaque complexity in hypercholesterolemic pigs" @default.
• W2049064718 cites W1542731022 @default.
• W2049064718 cites W1967577682 @default.
• W2049064718 cites W1970346631 @default.
• W2049064718 cites W1976132628 @default.
• W2049064718 cites W1997005770 @default.
• W2049064718 cites W2024886887 @default.
• W2049064718 cites W2070854970 @default.
• W2049064718 cites W2080904659 @default.
• W2049064718 cites W2091814080 @default.
• W2049064718 cites W2092461792 @default.
• W2049064718 cites W2103480977 @default.
• W2049064718 cites W2117187480 @default.
• W2049064718 cites W2119241926 @default.
• W2049064718 cites W2122115743 @default.
• W2049064718 cites W2126915336 @default.
• W2049064718 cites W2130541883 @default.
• W2049064718 cites W2131385716 @default.
• W2049064718 cites W2138119979 @default.
• W2049064718 cites W2141556979 @default.
• W2049064718 cites W2143064104 @default.
• W2049064718 cites W2149999963 @default.
• W2049064718 cites W2151426663 @default.
• W2049064718 cites W2160094856 @default.
• W2049064718 cites W2164616818 @default.
• W2049064718 cites W2169165196 @default.
• W2049064718 cites W2169704861 @default.
• W2049064718 cites W4250019141 @default.
• W2049064718 doi "https://doi.org/10.1111/j.1538-7836.2007.02786.x" @default.
• W2049064718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17922810" @default.
• W2049064718 hasPublicationYear "2007" @default.
• W2049064718 type Work @default.
• W2049064718 sameAs 2049064718 @default.
• W2049064718 citedByCount "28" @default.
• W2049064718 countsByYear W20490647182012 @default.
• W2049064718 countsByYear W20490647182013 @default.
• W2049064718 countsByYear W20490647182014 @default.
• W2049064718 countsByYear W20490647182015 @default.
• W2049064718 countsByYear W20490647182016 @default.
• W2049064718 countsByYear W20490647182017 @default.
• W2049064718 countsByYear W20490647182019 @default.
• W2049064718 countsByYear W20490647182020 @default.
• W2049064718 countsByYear W20490647182022 @default.
• W2049064718 crossrefType "journal-article" @default.
• W2049064718 hasAuthorship W2049064718A5007259656 @default.
• W2049064718 hasAuthorship W2049064718A5020839507 @default.
• W2049064718 hasAuthorship W2049064718A5026981224 @default.
• W2049064718 hasAuthorship W2049064718A5055695135 @default.
• W2049064718 hasAuthorship W2049064718A5062095347 @default.
• W2049064718 hasAuthorship W2049064718A5075714080 @default.
• W2049064718 hasBestOaLocation W20490647181 @default.
• W2049064718 hasConcept C104317684 @default.
• W2049064718 hasConcept C126322002 @default.
• W2049064718 hasConcept C137061746 @default.
• W2049064718 hasConcept C149011108 @default.
• W2049064718 hasConcept C202751555 @default.
• W2049064718 hasConcept C203014093 @default.
• W2049064718 hasConcept C204232928 @default.
• W2049064718 hasConcept C2776070231 @default.
• W2049064718 hasConcept C2776914184 @default.
• W2049064718 hasConcept C2777704780 @default.
• W2049064718 hasConcept C2777895019 @default.
• W2049064718 hasConcept C2778163477 @default.
• W2049064718 hasConcept C2778213512 @default.
• W2049064718 hasConcept C2778710248 @default.
• W2049064718 hasConcept C2780072125 @default.
• W2049064718 hasConcept C2781184567 @default.
• W2049064718 hasConcept C2781236682 @default.
• W2049064718 hasConcept C2991716557 @default.
• W2049064718 hasConcept C4224716 @default.
• W2049064718 hasConcept C55493867 @default.
• W2049064718 hasConcept C71924100 @default.
• W2049064718 hasConcept C86803240 @default.
• W2049064718 hasConceptScore W2049064718C104317684 @default.
• W2049064718 hasConceptScore W2049064718C126322002 @default.
• W2049064718 hasConceptScore W2049064718C137061746 @default.
• W2049064718 hasConceptScore W2049064718C149011108 @default.
• W2049064718 hasConceptScore W2049064718C202751555 @default.
• W2049064718 hasConceptScore W2049064718C203014093 @default.
• W2049064718 hasConceptScore W2049064718C204232928 @default.
• W2049064718 hasConceptScore W2049064718C2776070231 @default.
• W2049064718 hasConceptScore W2049064718C2776914184 @default.
• W2049064718 hasConceptScore W2049064718C2777704780 @default.
• W2049064718 hasConceptScore W2049064718C2777895019 @default.
• W2049064718 hasConceptScore W2049064718C2778163477 @default.
• W2049064718 hasConceptScore W2049064718C2778213512 @default.
• W2049064718 hasConceptScore W2049064718C2778710248 @default.
• W2049064718 hasConceptScore W2049064718C2780072125 @default.

• next