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• W2049084804 startingPage "17" @default.
• W2049084804 abstract "Glucocorticoids (GC) are probably the most important drugs in the treatment of ALL. Despite the extensive use of GC for many years, little is known about the molecular mechanisms of sensitivity and resistance. This review summarizes the knowledge on GC cytotoxicity in leukemia. The relevance of polymorphisms, splice variants and the number and regulation of the GC receptor are discussed. The role of multidrug resistance proteins, glutathione and glutathione S-transferase is evaluated, as well as the influence of the different heat-shock chaperone (hsp 90 and 70) and co-chaperone proteins (BAG-1 and others) which form a complex together with the GC receptor. Finally, the transactivation and transrepression (via NF-kappa B and AP-1 binding) of a wide range of genes (like c-myc) which initiates the final apoptosis pathway are discussed and suggestions for future directions of research in ALL patients are given." @default.
• W2049084804 created "2016-06-24" @default.
• W2049084804 creator A5035292815 @default.
• W2049084804 creator A5035786690 @default.
• W2049084804 creator A5051553596 @default.
• W2049084804 creator A5075070173 @default.
• W2049084804 date "2003-01-01" @default.
• W2049084804 modified "2023-10-16" @default.
• W2049084804 title "Molecular determinants of glucocorticoid sensitivity and resistance in acute lymphoblastic leukemia" @default.
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