FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049085196> ?p ?o ?g. }

• W2049085196 endingPage "283" @default.
• W2049085196 startingPage "275" @default.
• W2049085196 abstract "Suppression of increased bone resorption is an important issue in treatment of post-menopausal osteoporosis. Celecoxib is a highly selective inhibitor of cyclooxygenase-2 (COX-2), and inhibits osteoclastogenesis in vitro. In the present study, to test whether celecoxib can suppress elevated bone resorption caused by estrogen deficiency in vivo, celecoxib (4 mg/kg) or its vehicle was administered to sham-operated or ovariectomized (OVX) mice (model of post-menopausal osteoporosis). The treatment with celecoxib or vehicle was started immediately after the sham operation or ovariectomy, and lasted for 4 weeks. At 2 and 4 weeks after surgery, OVX mice administered vehicle had significantly higher levels of C-telopeptide, a marker of bone resorption in serum, than sham-operated mice administered vehicle (37% and 60% higher, respectively; p<0.01). At 2 and 4 weeks after surgery, celecoxib treatment significantly decreased serum C-telopeptide levels in OVX mice, but not in sham-operated mice (45% and 41%, respectively; p<0.001). In contrast, in both sham-operated and OVX mice, celecoxib did not significantly affect serum osteocalcin levels (a marker of bone formation) or bone mineral density (BMD) of the femur, which was evaluated by peripheral quantitative computed tomography (pQCT). In conclusion, treating OVX mice with celecoxib significantly suppressed the increase in serum levels of the bone resorption marker, but did not affect levels of the bone formation marker. Also, celecoxib did not prevent the decrease of femoral BMD in OVX mice. The present study suggests the possibility that celecoxib may be used to prevent bone loss caused by estrogen deficiency." @default.
• W2049085196 created "2016-06-24" @default.
• W2049085196 creator A5006309772 @default.
• W2049085196 creator A5023668927 @default.
• W2049085196 creator A5024383216 @default.
• W2049085196 creator A5054497725 @default.
• W2049085196 creator A5061665469 @default.
• W2049085196 creator A5070505728 @default.
• W2049085196 creator A5078802338 @default.
• W2049085196 creator A5081306982 @default.
• W2049085196 date "2007-01-01" @default.
• W2049085196 modified "2023-09-30" @default.
• W2049085196 title "The Selective Cyclooxygenase-2 Inhibitor Celecoxib Reduces Bone Resorption, but not Bone Formation, in Ovariectomized Mice in Vivo" @default.
• W2049085196 cites W1892257529 @default.
• W2049085196 cites W1973074971 @default.
• W2049085196 cites W2020563114 @default.
• W2049085196 cites W2062028959 @default.
• W2049085196 cites W2079641069 @default.
• W2049085196 cites W2091071821 @default.
• W2049085196 cites W2095093072 @default.
• W2049085196 cites W2097757541 @default.
• W2049085196 cites W2100200742 @default.
• W2049085196 cites W2102817784 @default.
• W2049085196 cites W2125471714 @default.
• W2049085196 cites W2126446849 @default.
• W2049085196 cites W2135393211 @default.
• W2049085196 cites W2152017468 @default.
• W2049085196 cites W2160465469 @default.
• W2049085196 cites W2725056820 @default.
• W2049085196 cites W4238345612 @default.
• W2049085196 cites W4240904020 @default.
• W2049085196 cites W4256054685 @default.
• W2049085196 doi "https://doi.org/10.1620/tjem.211.275" @default.
• W2049085196 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17347553" @default.
• W2049085196 hasPublicationYear "2007" @default.
• W2049085196 type Work @default.
• W2049085196 sameAs 2049085196 @default.
• W2049085196 citedByCount "15" @default.
• W2049085196 countsByYear W20490851962012 @default.
• W2049085196 countsByYear W20490851962013 @default.
• W2049085196 countsByYear W20490851962015 @default.
• W2049085196 countsByYear W20490851962016 @default.
• W2049085196 countsByYear W20490851962017 @default.
• W2049085196 countsByYear W20490851962019 @default.
• W2049085196 countsByYear W20490851962022 @default.
• W2049085196 countsByYear W20490851962023 @default.
• W2049085196 crossrefType "journal-article" @default.
• W2049085196 hasAuthorship W2049085196A5006309772 @default.
• W2049085196 hasAuthorship W2049085196A5023668927 @default.
• W2049085196 hasAuthorship W2049085196A5024383216 @default.
• W2049085196 hasAuthorship W2049085196A5054497725 @default.
• W2049085196 hasAuthorship W2049085196A5061665469 @default.
• W2049085196 hasAuthorship W2049085196A5070505728 @default.
• W2049085196 hasAuthorship W2049085196A5078802338 @default.
• W2049085196 hasAuthorship W2049085196A5081306982 @default.
• W2049085196 hasBestOaLocation W20490851961 @default.
• W2049085196 hasConcept C126322002 @default.
• W2049085196 hasConcept C131075544 @default.
• W2049085196 hasConcept C134018914 @default.
• W2049085196 hasConcept C146562846 @default.
• W2049085196 hasConcept C150903083 @default.
• W2049085196 hasConcept C160160445 @default.
• W2049085196 hasConcept C170033053 @default.
• W2049085196 hasConcept C181199279 @default.
• W2049085196 hasConcept C185592680 @default.
• W2049085196 hasConcept C207001950 @default.
• W2049085196 hasConcept C2776467144 @default.
• W2049085196 hasConcept C2776541429 @default.
• W2049085196 hasConcept C2776886416 @default.
• W2049085196 hasConcept C2777164284 @default.
• W2049085196 hasConcept C2777251235 @default.
• W2049085196 hasConcept C2779689624 @default.
• W2049085196 hasConcept C55493867 @default.
• W2049085196 hasConcept C673006 @default.
• W2049085196 hasConcept C71924100 @default.
• W2049085196 hasConcept C8264082 @default.
• W2049085196 hasConcept C86803240 @default.
• W2049085196 hasConceptScore W2049085196C126322002 @default.
• W2049085196 hasConceptScore W2049085196C131075544 @default.
• W2049085196 hasConceptScore W2049085196C134018914 @default.
• W2049085196 hasConceptScore W2049085196C146562846 @default.
• W2049085196 hasConceptScore W2049085196C150903083 @default.
• W2049085196 hasConceptScore W2049085196C160160445 @default.
• W2049085196 hasConceptScore W2049085196C170033053 @default.
• W2049085196 hasConceptScore W2049085196C181199279 @default.
• W2049085196 hasConceptScore W2049085196C185592680 @default.
• W2049085196 hasConceptScore W2049085196C207001950 @default.
• W2049085196 hasConceptScore W2049085196C2776467144 @default.
• W2049085196 hasConceptScore W2049085196C2776541429 @default.
• W2049085196 hasConceptScore W2049085196C2776886416 @default.
• W2049085196 hasConceptScore W2049085196C2777164284 @default.
• W2049085196 hasConceptScore W2049085196C2777251235 @default.
• W2049085196 hasConceptScore W2049085196C2779689624 @default.
• W2049085196 hasConceptScore W2049085196C55493867 @default.
• W2049085196 hasConceptScore W2049085196C673006 @default.
• W2049085196 hasConceptScore W2049085196C71924100 @default.
• W2049085196 hasConceptScore W2049085196C8264082 @default.
• W2049085196 hasConceptScore W2049085196C86803240 @default.

• next