FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049086289> ?p ?o ?g. }

• W2049086289 endingPage "50" @default.
• W2049086289 startingPage "43" @default.
• W2049086289 abstract "The urethral duct and vagina are formed from the urogenital sinus (UGS) during the early neonatal period in mice. Neonatal estrogen exposure results in hypospadias, or the malpositioning of vaginal and urethral openings, with wide cleft clitoris. We sought to characterize diethylstilbestrol (DES) influence on UGS morphogenesis and hypospadias formation. Newborn (day 0) and 1–4-day-old female mice (ICR/Jcl) were given (s.c.) oil or 3.0 μg DES. Animals were killed 24 hr later; then hypospadias formation and epithelial apoptosis and proliferation within the developing UGS were assessed. DES did not alter normal UGS morphogenesis by day 1, in comparison with controls. However, hypospadias formation was observed in DES-treated mice by day 3. In these mice, the distal dorsal urethral duct appeared to fuse with and open into the lower vaginal solid cord region. Further, DES treatment produced a gradual significant increase in dorsal urethral epithelial apoptosis (P < 0.05) just prior to and during fusion and hypospadias formation. DES-induced urethral epithelial and sinus cord proliferation appeared significantly increased (P < 0.05) and unchanged, respectively, just prior to fusion. By day 5, DES-treated mice exhibited wide cleft clitoris. In addition, if DES was given on day 3 or 5, a gradual, distinct caudal shift in the vaginal-urethral junction was observed compared to mice treated on days 0–2. Although hypospadias was not induced when neonates were given DES on day 7, these mice continued to display early vaginal opening. Dose-response analysis indicated that 0.03 μg DES for 5 days is the lowest known critical dose for hypospadias induction. We have shown for the first time that DES-induced hypospadias onset may primarily be the result of changes in developing dorsal urethral epithelial cell apoptotic and proliferative activity, and that the location of DES-induced hypospadias formation is dependent on age at time of exposure. Anat Rec 266:43–50, 2002. © 2002 Wiley-Liss, Inc." @default.
• W2049086289 created "2016-06-24" @default.
• W2049086289 creator A5005360431 @default.
• W2049086289 creator A5022463365 @default.
• W2049086289 creator A5031750107 @default.
• W2049086289 creator A5073399947 @default.
• W2049086289 creator A5085545545 @default.
• W2049086289 creator A5086045425 @default.
• W2049086289 date "2001-12-10" @default.
• W2049086289 modified "2023-10-14" @default.
• W2049086289 title "Characterization of diethylstilbestrol-induced hypospadias in female mice" @default.
• W2049086289 cites W1006217371 @default.
• W2049086289 cites W156242245 @default.
• W2049086289 cites W1855529383 @default.
• W2049086289 cites W1968614586 @default.
• W2049086289 cites W1998358577 @default.
• W2049086289 cites W2002372679 @default.
• W2049086289 cites W2007333440 @default.
• W2049086289 cites W2017302859 @default.
• W2049086289 cites W2022736585 @default.
• W2049086289 cites W2030269481 @default.
• W2049086289 cites W2038598495 @default.
• W2049086289 cites W2040753977 @default.
• W2049086289 cites W2052853635 @default.
• W2049086289 cites W2054127291 @default.
• W2049086289 cites W2060070668 @default.
• W2049086289 cites W2070542955 @default.
• W2049086289 cites W2083979723 @default.
• W2049086289 cites W2084709535 @default.
• W2049086289 cites W2136359610 @default.
• W2049086289 cites W2138302361 @default.
• W2049086289 cites W2166537089 @default.
• W2049086289 cites W2327758174 @default.
• W2049086289 doi "https://doi.org/10.1002/ar.10033" @default.
• W2049086289 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11748570" @default.
• W2049086289 hasPublicationYear "2001" @default.
• W2049086289 type Work @default.
• W2049086289 sameAs 2049086289 @default.
• W2049086289 citedByCount "33" @default.
• W2049086289 countsByYear W20490862892012 @default.
• W2049086289 countsByYear W20490862892013 @default.
• W2049086289 countsByYear W20490862892014 @default.
• W2049086289 countsByYear W20490862892015 @default.
• W2049086289 countsByYear W20490862892018 @default.
• W2049086289 countsByYear W20490862892019 @default.
• W2049086289 countsByYear W20490862892020 @default.
• W2049086289 countsByYear W20490862892021 @default.
• W2049086289 countsByYear W20490862892022 @default.
• W2049086289 crossrefType "journal-article" @default.
• W2049086289 hasAuthorship W2049086289A5005360431 @default.
• W2049086289 hasAuthorship W2049086289A5022463365 @default.
• W2049086289 hasAuthorship W2049086289A5031750107 @default.
• W2049086289 hasAuthorship W2049086289A5073399947 @default.
• W2049086289 hasAuthorship W2049086289A5085545545 @default.
• W2049086289 hasAuthorship W2049086289A5086045425 @default.
• W2049086289 hasBestOaLocation W20490862891 @default.
• W2049086289 hasConcept C105702510 @default.
• W2049086289 hasConcept C126322002 @default.
• W2049086289 hasConcept C16685009 @default.
• W2049086289 hasConcept C2777085111 @default.
• W2049086289 hasConcept C2777164284 @default.
• W2049086289 hasConcept C2777744392 @default.
• W2049086289 hasConcept C2777990738 @default.
• W2049086289 hasConcept C2780091579 @default.
• W2049086289 hasConcept C2781397067 @default.
• W2049086289 hasConcept C71924100 @default.
• W2049086289 hasConcept C85380620 @default.
• W2049086289 hasConceptScore W2049086289C105702510 @default.
• W2049086289 hasConceptScore W2049086289C126322002 @default.
• W2049086289 hasConceptScore W2049086289C16685009 @default.
• W2049086289 hasConceptScore W2049086289C2777085111 @default.
• W2049086289 hasConceptScore W2049086289C2777164284 @default.
• W2049086289 hasConceptScore W2049086289C2777744392 @default.
• W2049086289 hasConceptScore W2049086289C2777990738 @default.
• W2049086289 hasConceptScore W2049086289C2780091579 @default.
• W2049086289 hasConceptScore W2049086289C2781397067 @default.
• W2049086289 hasConceptScore W2049086289C71924100 @default.
• W2049086289 hasConceptScore W2049086289C85380620 @default.
• W2049086289 hasIssue "1" @default.
• W2049086289 hasLocation W20490862891 @default.
• W2049086289 hasLocation W20490862892 @default.
• W2049086289 hasOpenAccess W2049086289 @default.
• W2049086289 hasPrimaryLocation W20490862891 @default.
• W2049086289 hasRelatedWork W2003117509 @default.
• W2049086289 hasRelatedWork W2039522250 @default.
• W2049086289 hasRelatedWork W2049086289 @default.
• W2049086289 hasRelatedWork W2168252077 @default.
• W2049086289 hasRelatedWork W2413946727 @default.
• W2049086289 hasRelatedWork W2444395396 @default.
• W2049086289 hasRelatedWork W2581024124 @default.
• W2049086289 hasRelatedWork W2809046047 @default.
• W2049086289 hasRelatedWork W2972720930 @default.
• W2049086289 hasRelatedWork W3025673952 @default.
• W2049086289 hasVolume "266" @default.
• W2049086289 isParatext "false" @default.
• W2049086289 isRetracted "false" @default.
• W2049086289 magId "2049086289" @default.
• W2049086289 workType "article" @default.