FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049087449> ?p ?o ?g. }

• W2049087449 endingPage "n/a" @default.
• W2049087449 startingPage "n/a" @default.
• W2049087449 abstract "Gentamicin (G) is a highly nephrotoxic aminoglucoside. It was used to experimentally induce nephrotoxicity in male Wistar rats. To find a drug capable of protecting the nephron we assayed a cardioprotector (trimetazidine, TMZ) and a hepatoprotector (N-acetyl cysteine, NAC). The rats were divided into six groups (n = 8): (A) control without drugs; (B) treated with 50 mg kg(-1) per day (i.p.) of G for 7 days; (C) diet supplemented with 20 mg kg(-1) per day of TMZ for 7 days; (D) treated with 10 mg kg(-1) per day (i.p.) of NAC for 7 days; (E) pretreated for 7 days with 20 mg kg(-1) per day of TMZ and during the following 7 days with G + TMZ; (F) pretreated for 7 days with 10 mg kg(-1) per day (i.p.) of NAC and during the following 7 days with G + NAC. Urea and creatinine as well as the excretion of urinary gamma-glutamyl transpeptidase (GGT(u)) and urinary N-acetyl-glucosaminidase (NAG(u)) were determined and structural and ultrastructural studies were carried out. Group B was used as a G-induced nephrotoxicity control. Pretreatment with TMZ (E) showed a protector effect against induced nephrotoxicity, with no biochemical or functional changes nor alterations in histoarchitecture or ultrastructure. Pretreatment with NAC (F) showed no protector effect against G-induced nephrotoxicity since no statistically significant differences were found with respect to the control group with G. We conclude that G-induced nephrotoxicity is attenuated by the cytoprotective effect of TMZ. We may infer that TMZ inhibits the reabsorption and consequently the accumulation of G in the proximal tubule cell." @default.
• W2049087449 created "2016-06-24" @default.
• W2049087449 creator A5037283606 @default.
• W2049087449 creator A5046375856 @default.
• W2049087449 creator A5049247676 @default.
• W2049087449 creator A5060556873 @default.
• W2049087449 date "2010-01-08" @default.
• W2049087449 modified "2023-09-26" @default.
• W2049087449 title "Attenuation of gentamicin-induced nephrotoxicity: trimetazidine versus N-acetyl cysteine" @default.
• W2049087449 cites W1512994377 @default.
• W2049087449 cites W1834144089 @default.
• W2049087449 cites W1899059409 @default.
• W2049087449 cites W1904462175 @default.
• W2049087449 cites W1974048083 @default.
• W2049087449 cites W1974372282 @default.
• W2049087449 cites W1984229760 @default.
• W2049087449 cites W2004028601 @default.
• W2049087449 cites W2050534450 @default.
• W2049087449 cites W2051142023 @default.
• W2049087449 cites W2074423903 @default.
• W2049087449 cites W2075455807 @default.
• W2049087449 cites W2080045599 @default.
• W2049087449 cites W2093017568 @default.
• W2049087449 cites W2096048295 @default.
• W2049087449 cites W2099922198 @default.
• W2049087449 cites W2116423780 @default.
• W2049087449 cites W2117581987 @default.
• W2049087449 cites W2121975223 @default.
• W2049087449 cites W2130266388 @default.
• W2049087449 cites W2130492341 @default.
• W2049087449 cites W2139723538 @default.
• W2049087449 cites W2147640676 @default.
• W2049087449 cites W2168809448 @default.
• W2049087449 cites W2395030214 @default.
• W2049087449 cites W2463894061 @default.
• W2049087449 doi "https://doi.org/10.1002/jat.1502" @default.
• W2049087449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20063365" @default.
• W2049087449 hasPublicationYear "2010" @default.
• W2049087449 type Work @default.
• W2049087449 sameAs 2049087449 @default.
• W2049087449 citedByCount "9" @default.
• W2049087449 countsByYear W20490874492013 @default.
• W2049087449 countsByYear W20490874492015 @default.
• W2049087449 countsByYear W20490874492016 @default.
• W2049087449 countsByYear W20490874492018 @default.
• W2049087449 countsByYear W20490874492022 @default.
• W2049087449 crossrefType "journal-article" @default.
• W2049087449 hasAuthorship W2049087449A5037283606 @default.
• W2049087449 hasAuthorship W2049087449A5046375856 @default.
• W2049087449 hasAuthorship W2049087449A5049247676 @default.
• W2049087449 hasAuthorship W2049087449A5060556873 @default.
• W2049087449 hasConcept C10146269 @default.
• W2049087449 hasConcept C126189478 @default.
• W2049087449 hasConcept C126322002 @default.
• W2049087449 hasConcept C134018914 @default.
• W2049087449 hasConcept C159641895 @default.
• W2049087449 hasConcept C185592680 @default.
• W2049087449 hasConcept C2775832221 @default.
• W2049087449 hasConcept C2777927741 @default.
• W2049087449 hasConcept C2778176769 @default.
• W2049087449 hasConcept C2780091579 @default.
• W2049087449 hasConcept C2780306776 @default.
• W2049087449 hasConcept C2780365088 @default.
• W2049087449 hasConcept C2781231759 @default.
• W2049087449 hasConcept C501593827 @default.
• W2049087449 hasConcept C55493867 @default.
• W2049087449 hasConcept C71924100 @default.
• W2049087449 hasConcept C77411442 @default.
• W2049087449 hasConcept C98274493 @default.
• W2049087449 hasConceptScore W2049087449C10146269 @default.
• W2049087449 hasConceptScore W2049087449C126189478 @default.
• W2049087449 hasConceptScore W2049087449C126322002 @default.
• W2049087449 hasConceptScore W2049087449C134018914 @default.
• W2049087449 hasConceptScore W2049087449C159641895 @default.
• W2049087449 hasConceptScore W2049087449C185592680 @default.
• W2049087449 hasConceptScore W2049087449C2775832221 @default.
• W2049087449 hasConceptScore W2049087449C2777927741 @default.
• W2049087449 hasConceptScore W2049087449C2778176769 @default.
• W2049087449 hasConceptScore W2049087449C2780091579 @default.
• W2049087449 hasConceptScore W2049087449C2780306776 @default.
• W2049087449 hasConceptScore W2049087449C2780365088 @default.
• W2049087449 hasConceptScore W2049087449C2781231759 @default.
• W2049087449 hasConceptScore W2049087449C501593827 @default.
• W2049087449 hasConceptScore W2049087449C55493867 @default.
• W2049087449 hasConceptScore W2049087449C71924100 @default.
• W2049087449 hasConceptScore W2049087449C77411442 @default.
• W2049087449 hasConceptScore W2049087449C98274493 @default.
• W2049087449 hasLocation W20490874491 @default.
• W2049087449 hasLocation W20490874492 @default.
• W2049087449 hasOpenAccess W2049087449 @default.
• W2049087449 hasPrimaryLocation W20490874491 @default.
• W2049087449 hasRelatedWork W2128904764 @default.
• W2049087449 hasRelatedWork W2158992106 @default.
• W2049087449 hasRelatedWork W2395253036 @default.
• W2049087449 hasRelatedWork W2902628420 @default.
• W2049087449 hasRelatedWork W3016376068 @default.
• W2049087449 hasRelatedWork W3025255853 @default.
• W2049087449 hasRelatedWork W3038056575 @default.

• next