FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049088975> ?p ?o ?g. }

• W2049088975 endingPage "990" @default.
• W2049088975 startingPage "986" @default.
• W2049088975 abstract "The endoribonuclease Dicer is a key factor in the production of microRNAs. The deregulation of microRNA expression and potentially Dicer itself have been implicated in cancer. Elsa Flores and colleagues now show that TAp63, a member of the p53 family of tumour suppressors, suppresses tumorigenesis and metastasis by directly controlling the expression of Dicer and Dicer-regulated microRNAs. The aberrant expression of microRNAs and of the enzymes that control their processing has been reported in tumours, but the mechanisms involved are not clear. It is now shown that TAp63, a member of the p53 family of tumour suppressors, suppresses tumorigeneis and metastasis by directly controlling the expression of Dicer (a microRNA-processing enzyme) and Dicer-regulated microRNAs. Aberrant expression of microRNAs (miRNAs) and the enzymes that control their processing have been reported in multiple biological processes including primary and metastatic tumours1,2,3,4,5,6, but the mechanisms governing this are not clearly understood. Here we show that TAp63, a p53 family member, suppresses tumorigenesis and metastasis, and coordinately regulates Dicer and miR-130b to suppress metastasis. Metastatic mouse and human tumours deficient in TAp63 express Dicer at very low levels, and we found that modulation of expression of Dicer and miR-130b markedly affected the metastatic potential of cells lacking TAp63. TAp63 binds to and transactivates the Dicer promoter, demonstrating direct transcriptional regulation of Dicer by TAp63. These data provide a novel understanding of the roles of TAp63 in tumour and metastasis suppression through the coordinate transcriptional regulation of Dicer and miR-130b and may have implications for the many processes regulated by miRNAs." @default.
• W2049088975 created "2016-06-24" @default.
• W2049088975 creator A5005857392 @default.
• W2049088975 creator A5014809032 @default.
• W2049088975 creator A5019650612 @default.
• W2049088975 creator A5028085268 @default.
• W2049088975 creator A5031457070 @default.
• W2049088975 creator A5036444923 @default.
• W2049088975 creator A5042417560 @default.
• W2049088975 creator A5049425681 @default.
• W2049088975 creator A5053401529 @default.
• W2049088975 creator A5055671762 @default.
• W2049088975 creator A5077859412 @default.
• W2049088975 creator A5078173230 @default.
• W2049088975 date "2010-10-20" @default.
• W2049088975 modified "2023-09-26" @default.
• W2049088975 title "TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs" @default.
• W2049088975 cites W1994061059 @default.
• W2049088975 cites W1994772304 @default.
• W2049088975 cites W2005013681 @default.
• W2049088975 cites W2014938226 @default.
• W2049088975 cites W2016731068 @default.
• W2049088975 cites W2026203131 @default.
• W2049088975 cites W2034882416 @default.
• W2049088975 cites W2047529648 @default.
• W2049088975 cites W2063751533 @default.
• W2049088975 cites W2069144282 @default.
• W2049088975 cites W2075430446 @default.
• W2049088975 cites W2077330022 @default.
• W2049088975 cites W2077971105 @default.
• W2049088975 cites W2078242867 @default.
• W2049088975 cites W2079852484 @default.
• W2049088975 cites W2088740611 @default.
• W2049088975 cites W2090494026 @default.
• W2049088975 cites W2100369185 @default.
• W2049088975 cites W2102059693 @default.
• W2049088975 cites W2112881364 @default.
• W2049088975 cites W2117933664 @default.
• W2049088975 cites W2122205306 @default.
• W2049088975 cites W2130979840 @default.
• W2049088975 cites W2138689567 @default.
• W2049088975 cites W2144154026 @default.
• W2049088975 cites W2149848115 @default.
• W2049088975 cites W2150507760 @default.
• W2049088975 cites W2417280622 @default.
• W2049088975 doi "https://doi.org/10.1038/nature09459" @default.
• W2049088975 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3055799" @default.
• W2049088975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20962848" @default.
• W2049088975 hasPublicationYear "2010" @default.
• W2049088975 type Work @default.
• W2049088975 sameAs 2049088975 @default.
• W2049088975 citedByCount "384" @default.
• W2049088975 countsByYear W20490889752012 @default.
• W2049088975 countsByYear W20490889752013 @default.
• W2049088975 countsByYear W20490889752014 @default.
• W2049088975 countsByYear W20490889752015 @default.
• W2049088975 countsByYear W20490889752016 @default.
• W2049088975 countsByYear W20490889752017 @default.
• W2049088975 countsByYear W20490889752018 @default.
• W2049088975 countsByYear W20490889752019 @default.
• W2049088975 countsByYear W20490889752020 @default.
• W2049088975 countsByYear W20490889752021 @default.
• W2049088975 countsByYear W20490889752022 @default.
• W2049088975 countsByYear W20490889752023 @default.
• W2049088975 crossrefType "journal-article" @default.
• W2049088975 hasAuthorship W2049088975A5005857392 @default.
• W2049088975 hasAuthorship W2049088975A5014809032 @default.
• W2049088975 hasAuthorship W2049088975A5019650612 @default.
• W2049088975 hasAuthorship W2049088975A5028085268 @default.
• W2049088975 hasAuthorship W2049088975A5031457070 @default.
• W2049088975 hasAuthorship W2049088975A5036444923 @default.
• W2049088975 hasAuthorship W2049088975A5042417560 @default.
• W2049088975 hasAuthorship W2049088975A5049425681 @default.
• W2049088975 hasAuthorship W2049088975A5053401529 @default.
• W2049088975 hasAuthorship W2049088975A5055671762 @default.
• W2049088975 hasAuthorship W2049088975A5077859412 @default.
• W2049088975 hasAuthorship W2049088975A5078173230 @default.
• W2049088975 hasBestOaLocation W20490889752 @default.
• W2049088975 hasConcept C104317684 @default.
• W2049088975 hasConcept C119056186 @default.
• W2049088975 hasConcept C121608353 @default.
• W2049088975 hasConcept C145059251 @default.
• W2049088975 hasConcept C166703698 @default.
• W2049088975 hasConcept C2779013556 @default.
• W2049088975 hasConcept C2779867133 @default.
• W2049088975 hasConcept C502942594 @default.
• W2049088975 hasConcept C54355233 @default.
• W2049088975 hasConcept C555283112 @default.
• W2049088975 hasConcept C67705224 @default.
• W2049088975 hasConcept C86803240 @default.
• W2049088975 hasConcept C95444343 @default.
• W2049088975 hasConceptScore W2049088975C104317684 @default.
• W2049088975 hasConceptScore W2049088975C119056186 @default.
• W2049088975 hasConceptScore W2049088975C121608353 @default.
• W2049088975 hasConceptScore W2049088975C145059251 @default.
• W2049088975 hasConceptScore W2049088975C166703698 @default.
• W2049088975 hasConceptScore W2049088975C2779013556 @default.
• W2049088975 hasConceptScore W2049088975C2779867133 @default.

• next