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- W2049093012 abstract "Optimization via experimentation in iontophoresis was investigated. A response surface method was applied in optimizing the operating conditions in iontophoretic transdermal delivery of pilocarpine. With an objective for a transitory application of pilocarpine, i.e. in diagnosis of cystic fibrosis or in treatment of hyperhydrosis, the best operating condition was achieved via a response surface method by adjusting the pH of the buffer, ionic strength, current amplitude and frequency of pulsed current or active temporal ratio based on unknown structural models with stationary or slowly varying optima in the region of interest. This method was easy to approach and efficient in seeking optimal experimental conditions for multiple variables and an unknown structural system. Satisfactory results in optimizing the operating conditions in iontophoretic transdermal delivery of pilocarpine were thereby achieved." @default.
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- W2049093012 date "1996-03-01" @default.
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- W2049093012 title "Response surface method as an approach to optimization of iontophoretic transdermal delivery of pilocarpine" @default.
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- W2049093012 doi "https://doi.org/10.1016/0378-5173(95)04238-5" @default.
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