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• W2049093604 abstract "The osteotropic interleukin-6 (IL-6) types of cytokines IL-6, IL-11, and leukemia inhibitory factor (LIF), but not oncostatin M, are expressed by human gingival fibroblasts, and their expressions are regulated by IL-1 and tumor necrosis factor-α (TNF-α). In the present study, we investigated whether signaling through Toll-like receptor 2 (TLR2) can affect the expression of these cytokines in human gingival fibroblasts. Lipopolysac-charide (LPS) from P. gingivalis was found to stimulate IL-6 and LIF mRNA and protein, but not IL-11 or OSM mRNA. Using two synthetic ligands acting specifically at TLR2 and siRNA knockdown of TLR2, we demonstrated the important role of TLR2 in the stimulation of IL-6 and LIF in gingival fibroblasts. Analysis of these data suggests that signaling through the innate immune system controls the expression of osteotropic cytokines in human gingival fibroblasts." @default.
• W2049093604 created "2016-06-24" @default.
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• W2049093604 date "2010-05-26" @default.
• W2049093604 modified "2023-10-18" @default.
• W2049093604 title "Stimulation of IL-6 Cytokines in Fibroblasts by Toll-like Receptors 2" @default.
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• W2049093604 doi "https://doi.org/10.1177/0022034510366898" @default.
• W2049093604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20505053" @default.
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