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- W2049100176 abstract "To spin trap hydroxyl radical (HO) with in vivo detection of the resultant radical adducts, the use of two spin traps, 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) and 5-diethoxyphosphoryl-5-methyl-1-pyrroline-N-oxide (DEPMPO) (10 mmol/kg) has been compared. In mice treatment with 5-aminolevulinic acid and Fe3+ resulted in detection of adducts of hydroxyl radicals (HO), but only with use of DEPMPO. Similarly, ‘HO adducts’ generated via nucleophilic substitution of SO4•− adducts formed in vivo could be observed only when using DEPMPO as the spin trap. The reasons for the differences observed between DEPMPO and DMPO are likely due to different in vivo lifetimes of their hydroxyl radical adducts. These results seem to be the first direct in vivo EPR detection of hydroxyl radical adducts." @default.
- W2049100176 created "2016-06-24" @default.
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- W2049100176 date "2010-01-01" @default.
- W2049100176 modified "2023-09-24" @default.
- W2049100176 title "DMPO Blocks Signaling, Activation, and Genomic Damage Induced by LPS in Macrophages" @default.
- W2049100176 doi "https://doi.org/10.1016/j.freeradbiomed.2010.10.591" @default.
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