Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049103746> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2049103746 endingPage "65" @default.
- W2049103746 startingPage "61" @default.
- W2049103746 abstract "Objective: This randomized, double-blind, placebo-controlled study with treatment lasting 16 weeks and withdrawal lasting 6 weeks tried to determine whether stopping nitrates has an effect on left-ventricular end-systolic volume in patients with heart failure who were chronically treated with captopril and diuretics. Patients and Methods: The study group comprised 29 patients with previous myocardial infarction, symptoms of mild-to-moderate heart failure, ejection fraction below 40%, no exercise-induced angina and no electrocardiographic signs of ischemia. After all patients had been treated with captopril (target dose: 25 mg twice daily), diuretics and the study drug (target dose: 40 mg isosorbide dinitrate twice daily or placebo) for 16 weeks, the study drug was withdrawn. The patients were then maintained on captopril and diuretics at constant doses for a 6-week withdrawal period. Radionuclide ventriculography with right-heart catheterization was performed at rest and during supine bicycle exercise after 16 weeks of double-blind treatment and at the end of the 6-week withdrawal period. Results: The changes in resting parameters following the withdrawal of the study drug were not different between the groups. At comparable maximum workload (placebo group 68 ± 15 W, nitrate group 68 ± 20 W), nitrate withdrawal caused a decrease in ejection fraction (placebo withdrawal: +0.8 ± 4.0%; nitrate withdrawal: –2.7 ± 4.3%, p < 0.02) and increases in left-ventricular end-diastolic volume (–9 ± 35 vs. 23 ± 48 ml, p < 0.02) and end-systolic volume (–9 ± 33 vs. +24 ± 47 ml; p < 0.01). Conclusion: The addition of nitrates to a baseline therapy with captopril and diuretics might reduce exercise-induced left-ventricular dilatation in patients with heart failure from coronary disease." @default.
- W2049103746 created "2016-06-24" @default.
- W2049103746 creator A5003385940 @default.
- W2049103746 creator A5018700566 @default.
- W2049103746 creator A5036520621 @default.
- W2049103746 creator A5079674552 @default.
- W2049103746 creator A5087613717 @default.
- W2049103746 date "2001-01-01" @default.
- W2049103746 modified "2023-09-26" @default.
- W2049103746 title "Effects of Chronic Nitrate Therapy on Left-Ventricular Volume in Patients with Heart Failure Secondary to Coronary Disease Already Treated with Captopril: A Withdrawal Study" @default.
- W2049103746 cites W1990534049 @default.
- W2049103746 cites W1991599780 @default.
- W2049103746 cites W1998135568 @default.
- W2049103746 cites W2011299702 @default.
- W2049103746 cites W2015461676 @default.
- W2049103746 cites W2018879787 @default.
- W2049103746 cites W2042231029 @default.
- W2049103746 cites W2042554280 @default.
- W2049103746 cites W2046383587 @default.
- W2049103746 cites W2059765196 @default.
- W2049103746 cites W2068214160 @default.
- W2049103746 cites W2068590921 @default.
- W2049103746 cites W2068820110 @default.
- W2049103746 cites W2080849598 @default.
- W2049103746 cites W2088770941 @default.
- W2049103746 cites W2338262993 @default.
- W2049103746 cites W2417341272 @default.
- W2049103746 cites W2427470035 @default.
- W2049103746 doi "https://doi.org/10.1159/000047347" @default.
- W2049103746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11423708" @default.
- W2049103746 hasPublicationYear "2001" @default.
- W2049103746 type Work @default.
- W2049103746 sameAs 2049103746 @default.
- W2049103746 citedByCount "2" @default.
- W2049103746 countsByYear W20491037462014 @default.
- W2049103746 countsByYear W20491037462015 @default.
- W2049103746 crossrefType "journal-article" @default.
- W2049103746 hasAuthorship W2049103746A5003385940 @default.
- W2049103746 hasAuthorship W2049103746A5018700566 @default.
- W2049103746 hasAuthorship W2049103746A5036520621 @default.
- W2049103746 hasAuthorship W2049103746A5079674552 @default.
- W2049103746 hasAuthorship W2049103746A5087613717 @default.
- W2049103746 hasConcept C125567185 @default.
- W2049103746 hasConcept C126322002 @default.
- W2049103746 hasConcept C142724271 @default.
- W2049103746 hasConcept C164705383 @default.
- W2049103746 hasConcept C204787440 @default.
- W2049103746 hasConcept C27081682 @default.
- W2049103746 hasConcept C2778198053 @default.
- W2049103746 hasConcept C2778425758 @default.
- W2049103746 hasConcept C2778535784 @default.
- W2049103746 hasConcept C2778949068 @default.
- W2049103746 hasConcept C2779479957 @default.
- W2049103746 hasConcept C42219234 @default.
- W2049103746 hasConcept C500558357 @default.
- W2049103746 hasConcept C71924100 @default.
- W2049103746 hasConcept C78085059 @default.
- W2049103746 hasConcept C84393581 @default.
- W2049103746 hasConceptScore W2049103746C125567185 @default.
- W2049103746 hasConceptScore W2049103746C126322002 @default.
- W2049103746 hasConceptScore W2049103746C142724271 @default.
- W2049103746 hasConceptScore W2049103746C164705383 @default.
- W2049103746 hasConceptScore W2049103746C204787440 @default.
- W2049103746 hasConceptScore W2049103746C27081682 @default.
- W2049103746 hasConceptScore W2049103746C2778198053 @default.
- W2049103746 hasConceptScore W2049103746C2778425758 @default.
- W2049103746 hasConceptScore W2049103746C2778535784 @default.
- W2049103746 hasConceptScore W2049103746C2778949068 @default.
- W2049103746 hasConceptScore W2049103746C2779479957 @default.
- W2049103746 hasConceptScore W2049103746C42219234 @default.
- W2049103746 hasConceptScore W2049103746C500558357 @default.
- W2049103746 hasConceptScore W2049103746C71924100 @default.
- W2049103746 hasConceptScore W2049103746C78085059 @default.
- W2049103746 hasConceptScore W2049103746C84393581 @default.
- W2049103746 hasIssue "2" @default.
- W2049103746 hasLocation W20491037461 @default.
- W2049103746 hasLocation W20491037462 @default.
- W2049103746 hasOpenAccess W2049103746 @default.
- W2049103746 hasPrimaryLocation W20491037461 @default.
- W2049103746 hasRelatedWork W138045305 @default.
- W2049103746 hasRelatedWork W1966890586 @default.
- W2049103746 hasRelatedWork W2045987832 @default.
- W2049103746 hasRelatedWork W2064798317 @default.
- W2049103746 hasRelatedWork W2121010227 @default.
- W2049103746 hasRelatedWork W2124181709 @default.
- W2049103746 hasRelatedWork W2371322233 @default.
- W2049103746 hasRelatedWork W2389670742 @default.
- W2049103746 hasRelatedWork W2622922034 @default.
- W2049103746 hasRelatedWork W2999308310 @default.
- W2049103746 hasVolume "95" @default.
- W2049103746 isParatext "false" @default.
- W2049103746 isRetracted "false" @default.
- W2049103746 magId "2049103746" @default.
- W2049103746 workType "article" @default.