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• W2049110292 abstract "Maintenance of nervous system function during periods of a deconditioning syndrome is important to prevent diminished psychological/behavioral, and physiological function observed during periods of bed rest, physical inactivity, and weightlessness. A main neurotransmitter is norepinephrine (NE), and its regulation yields insight into nervous system function. This research tested the hypotheses that, 1) deconditioning syndrome induced by simulated weightlessness of 9 days via the head-down tilt (HDT) model results in a blunted noradrenergic turnover rate in selected brain tissue and, 2) that exercise training acts as a countermeasure for these changes in noradrenergic activity. Male Sprague–Dawley rats (3 months, n = 60) were divided into either a HDT (HDT, n = 20), cage control (CAGE-CN, n = 20) or an exercise trained HDT (HDT-EX, n = 20) group. Each group was further subdivided into a saline (n = 10) or alpha-methyl-tyrosine (AM, n = 10) (200 mg/kg) injected subgroup. Animals in the HDT groups were tail suspended in a 30° head-down tilt position for 9 days. Norepinephrine turnover was determined 3 h following administration of saline or alpha-methyl-para-tyrosine. The NE turnover rate (ng gm−1·h−1) for the CN, HDT, and HDT-EX groups, respectively, were as follows: locus coeruleus, 63 ± 33, *134 ± 65, 85 ± 61; hypothalamus, 195 ± 50, *47 ± 47; *93 ± 34; cerebellum, 10 ± 18, *65 ± 15, *53 ± 19; cerebral cortex, 6 ± 20, *28 ± 15, *68 ± 22. (*Denotes significant difference from the control group at the p ⩽ 0.05 level of significance; +denotes significant difference from the HDT group at the p ⩽ 0.05 level of significance.) These findings suggest that: 1) norepinephrine turnover rate adapts in a tissue-specific manner following a 9-day tail suspension, 2) increased norepinephrine turnover rates and norepinephrine tissue content in the HDT group are consistent with neural adaptation to a chronic stress response." @default.
• W2049110292 created "2016-06-24" @default.
• W2049110292 creator A5004018811 @default.
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• W2049110292 date "1999-07-01" @default.
• W2049110292 modified "2023-09-26" @default.
• W2049110292 title "Brain Norepinephrine Changes With Simulated Weightlessness and Relation to Exercise Training" @default.
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• W2049110292 doi "https://doi.org/10.1016/s0031-9384(99)00030-x" @default.
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