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• W2049111431 abstract "Summary In this study a comparison of scanning near‐field optical microscopy with a traditional, well‐known microscopic technique like transmission electron microscopy is discussed. To establish a reliable and comparable method for high‐resolution scanning near‐field optical microscopy imaging of biological samples, the attention is focussed on cell sections. In particular, we present a study of ultrathin sections of Jurkat T‐cells and MDAMB453 cells. We show the relationship among the scanning near‐field optical microscopy (topographic and optical) images and the kind of embedding medium (resin), the sections thickness and the staining of the sample. For a complementary investigation atomic force microscopy measurements are carried out, as well. The study reveals that scanning near‐field optical microscopy technique on opportunely prepared thin sections can be applied successfully for investigation of the interior of the cells. Scanning near‐field optical microscopy and transmission electron microscopy allow to obtain different, however comparable, and complementary information of the cell sample." @default.
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• W2049111431 date "2008-03-01" @default.
• W2049111431 modified "2023-10-16" @default.
• W2049111431 title "SNOM on cell thin sections: observation of Jurkat and MDAMB453 cells" @default.
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• W2049111431 doi "https://doi.org/10.1111/j.1365-2818.2008.01925.x" @default.
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