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- W2049124853 abstract "We used an operant delayed spatial alternation task to examine the role of rat dorsomedial prefrontal cortex (dmPFC) in spatial working memory. The task was designed to restrict movements during the delay period to minimize use of motor-mediating strategies. Inactivation of dmPFC (muscimol) resulted in increased errors and increased the temporal variability of responding. Animals did not show perseveration after errors (i.e., responding again at the erroneous location). Under control conditions, the time between spatial responses was greater and more variable before errors as compared to correct responses. These effects were eliminated when muscimol was infused into dmPFC. Trial outcome also affected movement and delay times in the next trial. This effect was diminished with muscimol in dmPFC. By contrast, when muscimol was infused in dorsal agranular insular cortex (AId)-a region that is strongly interconnected with dorsomedial prefrontal regions-there was no effect on delayed spatial alternation performance. These experiments confirm that dmPFC is necessary for successful delayed spatial alternation and establish that there is a relationship between response time variability and trial outcome that depends on dorsomedial prefrontal function." @default.
- W2049124853 created "2016-06-24" @default.
- W2049124853 creator A5030298052 @default.
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- W2049124853 date "2009-12-01" @default.
- W2049124853 modified "2023-09-23" @default.
- W2049124853 title "The role of rat dorsomedial prefrontal cortex in spatial working memory" @default.
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- W2049124853 doi "https://doi.org/10.1016/j.neuroscience.2009.08.004" @default.
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