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• W2049128035 abstract "Objectives: Aspirin (ASA) is a potent antioxidative agent that reduces vascular production of superoxide, prevents angiotensin II-induced hypertension and cardiovascular hypertrophy, and induces nitric oxide release from vascular endothelium. Low-dose ASA has also been shown to reduce ambulatory blood pressure (BP) when administered at bedtime, as opposed to upon awakening, in pre-hypertensive as well as in untreated hypertensive subjects. We investigated clinical factors that, apart from time of treatment, could influence the response of ambulatory BP to low-dose ASA. Methods: We studied 316 untreated hypertensive subjects (130 men), 44.1 ± 13.2 years of age, assigned to receive aspirin (100 mg/day), in a prospective, open-label study, either on awakening or at bedtime. BP was measured every 20-min from 07:00 to 23:00 h and every 30-min at night for 48 h before after 3 months of treatment. Blood samples were obtained between 08:00 and 09:00 h after nocturnal fast. Results: Ambulatory BP was unchanged in subjects ingesting ASA on awakening. A significant ambulatory BP reduction was, however, observed in the subjects who received 100 mg/day ASA at bedtime (decrease of 7.0/4.7 mmHg in the 24 h systolic/diastolic BP mean; P < 0.001). The BP reduction after bedtime dosing was significantly larger for women (8.0/5.5 mmHg in systolic/diastolic BP) as compared to men (5.5/3.4 mmHg, respectively; P < 0.009 for gender differences). Multiple regression analysis indicated the BP-lowering after low-dose ASA was simultaneously and significantly related to bedtime treatment, female gender, higher baseline 24 h systolic BP mean, higher glomerular filtration rate, and the interaction between gender and treatment-time. For subjects ingesting ASA at bedtime, the significant factors influencing a higher BP reduction were female gender, higher baseline 24 h systolic BP mean, higher fasting glucose, and higher glomerular filtration rate. Conclusions: This prospective study corroborates the highly significant administration-time-dependent effect of low-dose ASA on ambulatory BP. The BP response to ASA ingested at bedtime is significantly larger in women as compared to men, as well as in subjects with impaired fasting glucose and preserved renal function." @default.
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• W2049128035 date "2010-06-01" @default.
• W2049128035 modified "2023-09-28" @default.
• W2049128035 title "FACTORS INFLUENCING THE AMBULATORY BLOOD PRESSURE RESPONSE TO LOW-DOSE ASPIRIN IN SUBJECTS WITH UNTREATED MILD HYPERTENSION: PP.16.103" @default.
• W2049128035 doi "https://doi.org/10.1097/01.hjh.0000379029.50471.41" @default.
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