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- W2049128045 abstract "Hemozoin, a heme byproduct of hemoglobin digestion by malaria parasites, is released into the blood stream of the host upon lysing of infected erythrocytes. Since heme-compounds are potent catalysts of lipid peroxidation, we evaluated the catalytic ability of Plasmodium falciparum-derived hemozoin to oxidize arachidonic acid to hydroxyei-cosatetraenoic acids (HETEs). Hemozoin, β-hematin, and hematin all catalyzed the formation of 15-, 12- and 5-HETE as major products. Although there were no significant differences in total amounts of HETEs generated by hemozoin relative to hematin or β-hematin, there were significant differences in the proportions of certain isomers. 15-HETE was the predominant isomer generated by hemozoin catalysis while 5-HETE was the major product formed by hematin catalysis. Since HETEs are important vasoactive mediators, the non-enzymatic oxidation of arachidonic acid by hemozoin catalysis may contribute to some of the pathophysiology associated with severe and cerebral malaria." @default.
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- W2049128045 date "1996-12-20" @default.
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- W2049128045 title "Formation of hydroxyeicosatetraenoic acids from hemozoin-catalyzed oxidation of arachidonic acid" @default.
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- W2049128045 doi "https://doi.org/10.1016/s0166-6851(96)02769-7" @default.
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