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- W2049132741 abstract "Microenvironmental changes including elevated levels of L-glutamate, ionic homeostasis, acidification, and oxygen level are associated with brain insults. Their effects on energy metabolism were studied in cultured astrocytes. L-glutamate caused a decrease in lactate accumulation through the activation of transporter in astrocytes in a concentration- and time-dependent manner. Decreases in glucose uptake, lactate synthesis and accumulation as well as increases in mitochondrial activity indicated a switch of the astrocytic metabolism from glycolytic to oxidative. Environmental changes co-operated with L-glutamate to regulate the metabolic strategy, e.g. KCl and oxygen deprivation reversed but acidification exacerbated the L-glutamate-mediated decrease in lactate accumulation. Taken together, during chronic exposure, oxidation of non-glucose substrates such as L-glutamate fuels the active transport of L-glutamate into astrocytes." @default.
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- W2049132741 date "2003-09-01" @default.
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- W2049132741 title "l-Glutamate decreases glucose utilization by rat cortical astrocytes" @default.
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- W2049132741 doi "https://doi.org/10.1016/s0304-3940(03)00721-3" @default.
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