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• W2049144012 abstract "The antinociceptive effects of intracerebroventricular (ICV) administration of histogranin (HN) and related peptides were assessed in the mouse writhing and tail-flick assays. In the writhing test, the peptides displayed dose-dependent analgesic effects with an AD50 of 23.9 nmol/mouse for HN and the following order for other peptides: HN-(7–15)<histone H4-(86–100)≈HN≈HN-(7–10)<[Ser1]HN<osteogenic growth peptide (OGP)≈HN-(1–10). HN-(6–9) and HN-(8–10) did not show any significant analgesic activity at 50 nmol/mouse. The importance of the C- and N-terminal amino acids in the analgesic activity of the peptides was demonstrated by the prolonged effects of HN and [Ser1]HN (≈30 min) compared with those of HN fragments (HN-(7–15), HN-(1–10) and HN-(7–10): 5–10 min). The analgesic activity of [Ser1]HN (50 nmol/mouse) was not affected by the coadministration of opioid (naloxone, 1 nmol/mouse), NMDA (CPP, 0.3 and MK-801, 0.3 nmol/mouse) and D1 (SCH-23390, 0.5 nmol/mouse) receptor antagonists, but it was significantly antagonized by the coinjection of the D2 receptor antagonist raclopride (0.5 nmol/mouse). In the mouse tail-flick assay, HN and related peptides (50 nmol/mouse) also showed significant analgesic activity (15–35% MPE). The analgesic effect of [Ser1]HN was dose-dependent and, at 75 nmol/mouse, lasted for up to 45 min, and was partially blocked by the coadministration of raclopride (1 nmol/mouse), but not naloxone (2 nmol/mouse). In the mouse rotarod assay, relative high doses (75–100 nmol/mouse) of HN and related peptides did not significantly affect motor coordination. These results indicate that supraspinal administration of HN and related peptides induce significant non-opioid analgesic effects devoid of motor activity by a mechanism that involves the participation of central dopamine D2 receptors." @default.
• W2049144012 created "2016-06-24" @default.
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• W2049144012 date "2000-09-01" @default.
• W2049144012 modified "2023-09-27" @default.
• W2049144012 title "Non-opioid antinociceptive effects of supraspinal histogranin and related peptides: possible involvement of central dopamine D2 receptor" @default.
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• W2049144012 doi "https://doi.org/10.1016/s0091-3057(00)00308-7" @default.
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