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• W2049144428 abstract "Although most cases of eosinophilic granuloma (an immune-mediated lesion) do not behave in an aggressive manner, occasionally, recurrence after treatment has been observed. This study aims to investigate the significance and relationship of matrix metalloproteinase-9 (MMP-9) and infiltration of macrophages in eosinophilic granulomas (EGs). The immunohistochemical strept avidin-biotin complex method was used to detect the expression of MMP-9 and CD-68 (for labeling macrophages) in 13 cases of EG. Three of whom showed local recurrence. The results showed that many of the Langerhans histiocytic cells, which reacted positively with MMP-9 protein antibody, were immunolabeled with CD-68 antibody. The results showed that there is a highly significant relationship between the expression of MMP-9 and macrophage count in EGs (P < .001), with recurrent lesions showing a higher mean expression of both MMP-9 and CD-68. In conclusion, there may be a cooperation between macrophages and MMP-9 in EGs, which correlates well with local recurrence. Their expression may therefore provide some prognostic indication of the possible aggressive and recurrence behavior of this lesion." @default.
• W2049144428 created "2016-06-24" @default.
• W2049144428 creator A5085037165 @default.
• W2049144428 date "2009-12-01" @default.
• W2049144428 modified "2023-09-23" @default.
• W2049144428 title "Expression of matrix metalloproteinase-9 and significance of a macrophage assay in eosinophilic granuloma" @default.
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• W2049144428 doi "https://doi.org/10.1016/j.anndiagpath.2009.06.009" @default.
• W2049144428 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19917471" @default.
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