FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049144486> ?p ?o ?g. }

• W2049144486 endingPage "5345" @default.
• W2049144486 startingPage "5341" @default.
• W2049144486 abstract "The beta-amyloid precursor protein (beta-APP), from which the beta-A4 peptide is derived, is considered to be central to the pathogenesis of Alzheimer disease (AD). Transgenic mice expressing the 751-amino acid isoform of human beta-APP (beta-APP751) have been shown to develop early AD-like histopathology with diffuse deposits of beta-A4 and aberrant tau protein expression in the brain, particularly in the hippocampus, cortex, and amygdala. We now report that beta-APP751 transgenic mice exhibit age-dependent deficits in spatial learning in a water-maze task and in spontaneous alternation in a Y maze. These deficits were mild or absent in 6-month-old transgenic mice but were severe in 12-month-old transgenic mice compared to age-matched wild-type control mice. No other behavioral abnormalities were observed. These mice therefore model the progressive learning and memory impairment that is a cardinal feature of AD. These results provide evidence for a relationship between abnormal expression of beta-APP and cognitive impairments." @default.
• W2049144486 created "2016-06-24" @default.
• W2049144486 creator A5031835127 @default.
• W2049144486 creator A5033718619 @default.
• W2049144486 creator A5034339136 @default.
• W2049144486 creator A5067624732 @default.
• W2049144486 date "1995-06-06" @default.
• W2049144486 modified "2023-09-25" @default.
• W2049144486 title "Age-related learning deficits in transgenic mice expressing the 751-amino acid isoform of human beta-amyloid precursor protein." @default.
• W2049144486 cites W1977809930 @default.
• W2049144486 cites W1982615582 @default.
• W2049144486 cites W1992176243 @default.
• W2049144486 cites W2024363942 @default.
• W2049144486 cites W2053341960 @default.
• W2049144486 cites W2058723245 @default.
• W2049144486 cites W2063964767 @default.
• W2049144486 cites W2064093411 @default.
• W2049144486 cites W2066582197 @default.
• W2049144486 cites W2068173716 @default.
• W2049144486 cites W2069566607 @default.
• W2049144486 cites W2069682857 @default.
• W2049144486 cites W2070002886 @default.
• W2049144486 cites W2070008559 @default.
• W2049144486 cites W2077818261 @default.
• W2049144486 cites W2081569845 @default.
• W2049144486 cites W2090041950 @default.
• W2049144486 cites W2091855875 @default.
• W2049144486 cites W2094217020 @default.
• W2049144486 cites W2126800086 @default.
• W2049144486 cites W1993551004 @default.
• W2049144486 doi "https://doi.org/10.1073/pnas.92.12.5341" @default.
• W2049144486 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/41690" @default.
• W2049144486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7777509" @default.
• W2049144486 hasPublicationYear "1995" @default.
• W2049144486 type Work @default.
• W2049144486 sameAs 2049144486 @default.
• W2049144486 citedByCount "303" @default.
• W2049144486 countsByYear W20491444862012 @default.
• W2049144486 countsByYear W20491444862013 @default.
• W2049144486 countsByYear W20491444862014 @default.
• W2049144486 countsByYear W20491444862015 @default.
• W2049144486 countsByYear W20491444862016 @default.
• W2049144486 countsByYear W20491444862017 @default.
• W2049144486 countsByYear W20491444862018 @default.
• W2049144486 countsByYear W20491444862019 @default.
• W2049144486 countsByYear W20491444862020 @default.
• W2049144486 countsByYear W20491444862021 @default.
• W2049144486 countsByYear W20491444862022 @default.
• W2049144486 countsByYear W20491444862023 @default.
• W2049144486 crossrefType "journal-article" @default.
• W2049144486 hasAuthorship W2049144486A5031835127 @default.
• W2049144486 hasAuthorship W2049144486A5033718619 @default.
• W2049144486 hasAuthorship W2049144486A5034339136 @default.
• W2049144486 hasAuthorship W2049144486A5067624732 @default.
• W2049144486 hasBestOaLocation W20491444862 @default.
• W2049144486 hasConcept C102230213 @default.
• W2049144486 hasConcept C104317684 @default.
• W2049144486 hasConcept C126322002 @default.
• W2049144486 hasConcept C134018914 @default.
• W2049144486 hasConcept C141035611 @default.
• W2049144486 hasConcept C151484617 @default.
• W2049144486 hasConcept C169760540 @default.
• W2049144486 hasConcept C199360897 @default.
• W2049144486 hasConcept C2775847253 @default.
• W2049144486 hasConcept C2776156579 @default.
• W2049144486 hasConcept C2776174256 @default.
• W2049144486 hasConcept C2777633098 @default.
• W2049144486 hasConcept C2779134260 @default.
• W2049144486 hasConcept C2779144063 @default.
• W2049144486 hasConcept C2779281246 @default.
• W2049144486 hasConcept C2781161787 @default.
• W2049144486 hasConcept C31705614 @default.
• W2049144486 hasConcept C41008148 @default.
• W2049144486 hasConcept C502032728 @default.
• W2049144486 hasConcept C515207424 @default.
• W2049144486 hasConcept C53345823 @default.
• W2049144486 hasConcept C55493867 @default.
• W2049144486 hasConcept C59822182 @default.
• W2049144486 hasConcept C71924100 @default.
• W2049144486 hasConcept C86803240 @default.
• W2049144486 hasConceptScore W2049144486C102230213 @default.
• W2049144486 hasConceptScore W2049144486C104317684 @default.
• W2049144486 hasConceptScore W2049144486C126322002 @default.
• W2049144486 hasConceptScore W2049144486C134018914 @default.
• W2049144486 hasConceptScore W2049144486C141035611 @default.
• W2049144486 hasConceptScore W2049144486C151484617 @default.
• W2049144486 hasConceptScore W2049144486C169760540 @default.
• W2049144486 hasConceptScore W2049144486C199360897 @default.
• W2049144486 hasConceptScore W2049144486C2775847253 @default.
• W2049144486 hasConceptScore W2049144486C2776156579 @default.
• W2049144486 hasConceptScore W2049144486C2776174256 @default.
• W2049144486 hasConceptScore W2049144486C2777633098 @default.
• W2049144486 hasConceptScore W2049144486C2779134260 @default.
• W2049144486 hasConceptScore W2049144486C2779144063 @default.
• W2049144486 hasConceptScore W2049144486C2779281246 @default.
• W2049144486 hasConceptScore W2049144486C2781161787 @default.
• W2049144486 hasConceptScore W2049144486C31705614 @default.
• W2049144486 hasConceptScore W2049144486C41008148 @default.

• next