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- W2049149316 abstract "The combination of dexamethasone, etoposide (VP-16), ifosfamide and cisplatin (DVIP) was evaluated as a second line after adriamycin containing combinations in intermediate or high grade non-Hodgkin's lymphoma (NHL). 39 patients (pts) (median age 68 years) entered the study. Objective responses were seen in 29 pts (74%) and included complete response (CR) in 14 (36%). Median duration of CR was 12 months (mos) and that of partial response was 3.5 mos. 13/25 (52%) pts who responded with CR to adriamycin-based combinations responded with CR to DVIP (vs 1/14 who failed to respond with CR). Durable remissions (24 ± 57+ mos) continue in 4 pts who responded with CR to frontline therapy. Main toxicity was myelosuppression. Median WBC nadir was 1100/mm3 and median platelets nadir was 66,000/mm3. There was no treatment-related mortality. We conclude that DVIP is an effective second line in histologically aggressive NHL, associated with acceptable toxicity, and has a curative potential in pts with relapsing disease." @default.
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- W2049149316 date "1995-11-01" @default.
- W2049149316 modified "2023-09-27" @default.
- W2049149316 title "810 Dexamethasone, etoposide, ifosfamide and cisplatin as second-line chemotherapy in intermediate or high grade non-Hodgkin's lymphoma" @default.
- W2049149316 doi "https://doi.org/10.1016/0959-8049(95)96059-m" @default.
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