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• W2049158024 abstract "We evaluated the therapeutic effects of two noncompetitive antagonists of the N-methyl-d-aspartate (NMDA) receptor, MgCl2 and ketamine, both individually and together, on cognitive dysfunction observed following parasagittal fluid-percussion (FP) brain injury in the rat. Using a modified Morris water maze technique, we found significant attenuation of post-traumatic memory dysfunction in animals treated with either MgCl2 (125 μmol) or ketamine (4 mg/kg) (P < 0.005). Combined MgCl2 and ketamine treatment also preserved memory function (P < 0.005), with no apparent additive effect." @default.
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• W2049158024 date "1993-07-01" @default.
• W2049158024 modified "2023-09-25" @default.
• W2049158024 title "Magnesium and ketamine attenuate cognitive dysfunction following experimental brain injury" @default.
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• W2049158024 doi "https://doi.org/10.1016/0304-3940(93)90739-8" @default.
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