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- W2049165307 abstract "Abstract The metabolism of etrimfos, O,O -dimethyl- O -(6-ethoxy-2-ethyl-4-pyrimidinyl) phosphorothioate was studied in vitro in a diazinon-resistant (Rutgers) and a susceptible (CSMA) strain of house flies. Practically no metabolism of etrimfos occurred without the addition of cofactors. However, the addition of the cofactor, reduced glutathione, resulted in a substantial amount of metabolism in both strains, the metabolism being higher in the resistant strain. The major route of metabolism was via the glutathione transferase system and the predominant metabolite was desmethyl etrimfos. Although the oxygen analog could not be isolated, microsomal oxidation of etrimfos resulted in the inhibition of acetylcholinesterase, suggesting the formation of the oxygen analog. Bovine serum albumin also degraded etrimfos yielding desmethyl etrimfos and 6-ethoxy-2-ethyl-4-hydroxypyrimidine." @default.
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- W2049165307 date "1979-02-01" @default.
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- W2049165307 title "In vitro metabolism of etrimfos by house flies" @default.
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- W2049165307 doi "https://doi.org/10.1016/0048-3575(79)90005-1" @default.
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