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- W2049165747 abstract "The neurobiological mechanisms of emotional modulation and the molecular pathophysiology of anxiety disorders are largely unknown. The fibroblast growth factor (FGF) family has been implicated in the regulation of many physiological and pathological processes, which include the control of emotional behaviors. The present study examined mice with a targeted deletion of the fgf-bp3 gene, which encodes a novel FGF-binding protein, in animal models relevant to anxiety. To define the behavioral consequences of FGF-BP3 deficiency, we evaluated fgf-bp3-deficient mice using anxiety-related behavioral paradigms that provide a conflict between the desire to explore an unknown area or objects and the aversion to a brightly lit open space. The fgf-bp3-deficient mice exhibited alterations in time spent in the central area of the open-field arena, were less active in the lit areas of a light/dark transition test, and had a prolonged latency to feed during a novelty-induced hypophagia test. These changes were associated with alterations in light-induced orbitofrontal cortex (OFC) activation in an extracellular signal-regulated kinase (ERK) pathway-dependent manner. These results demonstrate that FGF-BP3 is a potent mediator of anxiety-related behaviors in mice and suggest that distinct pathways regulate emotional behaviors. Therefore, FGF-BP3 plays a critical role in the regulation of emotional states and in the development of anxiety disorders and should be investigated as a therapeutic target for anxiety disease in humans." @default.
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- W2049165747 date "2011-01-01" @default.
- W2049165747 modified "2023-09-30" @default.
- W2049165747 title "Inactivation of fibroblast growth factor binding protein 3 causes anxiety-related behaviors" @default.
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- W2049165747 cites W1703928389 @default.
- W2049165747 cites W1710423957 @default.
- W2049165747 cites W1808638478 @default.
- W2049165747 cites W1967075670 @default.
- W2049165747 cites W1968173341 @default.
- W2049165747 cites W1971666872 @default.
- W2049165747 cites W1972251813 @default.
- W2049165747 cites W1972528511 @default.
- W2049165747 cites W1982428356 @default.
- W2049165747 cites W1982509041 @default.
- W2049165747 cites W1985195841 @default.
- W2049165747 cites W1985570109 @default.
- W2049165747 cites W1987850841 @default.
- W2049165747 cites W1989378157 @default.
- W2049165747 cites W1996962495 @default.
- W2049165747 cites W2001419142 @default.
- W2049165747 cites W2006819294 @default.
- W2049165747 cites W2007367045 @default.
- W2049165747 cites W2011812102 @default.
- W2049165747 cites W2014373387 @default.
- W2049165747 cites W2017727557 @default.
- W2049165747 cites W2023443471 @default.
- W2049165747 cites W2027368063 @default.
- W2049165747 cites W2030747778 @default.
- W2049165747 cites W2033202446 @default.
- W2049165747 cites W2035296124 @default.
- W2049165747 cites W2042665911 @default.
- W2049165747 cites W2046172352 @default.
- W2049165747 cites W2052867854 @default.
- W2049165747 cites W2053068006 @default.
- W2049165747 cites W2056304112 @default.
- W2049165747 cites W2058140544 @default.
- W2049165747 cites W2060341782 @default.
- W2049165747 cites W2079203942 @default.
- W2049165747 cites W2082179080 @default.
- W2049165747 cites W2082483640 @default.
- W2049165747 cites W2088743964 @default.
- W2049165747 cites W2091651881 @default.
- W2049165747 cites W2092245844 @default.
- W2049165747 cites W2095223509 @default.
- W2049165747 cites W2101721299 @default.
- W2049165747 cites W2103802045 @default.
- W2049165747 cites W2104202813 @default.
- W2049165747 cites W2105394148 @default.
- W2049165747 cites W2115204154 @default.
- W2049165747 cites W2120251526 @default.
- W2049165747 cites W2123128031 @default.
- W2049165747 cites W2124134886 @default.
- W2049165747 cites W2125000060 @default.
- W2049165747 cites W2125673642 @default.
- W2049165747 cites W2129656837 @default.
- W2049165747 cites W2138738238 @default.
- W2049165747 cites W2143733734 @default.
- W2049165747 cites W2144750899 @default.
- W2049165747 cites W2146948477 @default.
- W2049165747 cites W2146978055 @default.
- W2049165747 cites W2150092716 @default.
- W2049165747 cites W2155806637 @default.
- W2049165747 cites W2163663276 @default.
- W2049165747 cites W2165517240 @default.
- W2049165747 cites W2169747239 @default.
- W2049165747 cites W218056410 @default.
- W2049165747 cites W2335310975 @default.
- W2049165747 cites W2793634050 @default.
- W2049165747 cites W4296759713 @default.
- W2049165747 doi "https://doi.org/10.1016/j.mcn.2010.09.003" @default.
- W2049165747 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20851768" @default.
- W2049165747 hasPublicationYear "2011" @default.
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