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• W2049166174 abstract "Cellular stimuli generate reactive oxygen species (ROS) via the local action of NADPH oxidases (Nox) to modulate cytoskeletal organization and cell migration through unknown mechanisms. Cofilin is a major regulator of cellular actin dynamics whose activity is controlled by phosphorylation/dephosphorylation at Ser3. Here we show that Slingshot-1L (SSH-1L), a selective cofilin regulatory phosphatase, is involved in H(2)O(2)-induced cofilin dephosphorylation and activation. SSH-1L is activated by its release from a regulatory complex with 14-3-3zeta protein through the redox-mediated oxidation of 14-3-3zeta by H(2)O(2). The ROS-dependent activation of the SSH-1L-cofilin pathway stimulates the SSH-1L-dependent formation of cofilin-actin rods in cofilin-GFP-expressing HeLa cells. Similarly, the formation of endogenous ROS stimulated by angiotensin II (AngII) also activates the SSH-1L-cofilin pathway via oxidation of 14-3-3zeta to increase AngII-induced membrane ruffling and cell motility. These results suggest that the formation of ROS by NADPH oxidases engages a SSH-1L-cofilin pathway to regulate cytoskeletal organization and cell migration." @default.
• W2049166174 created "2016-06-24" @default.
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• W2049166174 date "2009-06-01" @default.
• W2049166174 modified "2023-09-24" @default.
• W2049166174 title "Reactive Oxygen Species Regulate a Slingshot-Cofilin Activation Pathway" @default.
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• W2049166174 doi "https://doi.org/10.1091/mbc.e09-02-0131" @default.
• W2049166174 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2688545" @default.
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