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• W2049183222 abstract "Summary Haemophilia A carriers have historically been thought to exhibit normal haemostasis. However, recent data demonstrates that, despite normal factor VIII ( FVIII ), haemophilia A carriers demonstrate an increased bleeding tendency. We tested the hypothesis that obligate haemophilia carriers exhibit an increase in clinically relevant bleeding. A cross‐sectional study was performed comparing haemophilia A carriers to normal women. Questionnaire assessment included a general bleeding questionnaire, condensed MCMDM ‐1 VWD bleeding assessment tool and Pictorial Bleeding Assessment Chart ( PBAC ). Laboratory assessment included complete blood count, prothrombin time, activated partial thromboplastin time, fibrinogen activity, FVIII activity ( FVIII :C), von Willebrand factor antigen level, ristocetin cofactor, platelet function analyser‐100 TM and ABO blood type. Forty‐four haemophilia A carriers and 43 controls were included. Demographic features were similar. Laboratory results demonstrated a statistically significant difference only in FVIII :C (82·5 vs. 134%, P < 0·001). Carriers reported a higher number of bleeding events, and both condensed MCMDM ‐1 VWD bleeding scores (5 vs. 1, P < 0·001) and PBAC scores (423 vs. 182·5, P = 0·018) were significantly higher in carriers. Haemophilia A carriers exhibit increased bleeding symptoms when compared to normal women. Further studies are necessary to fully understand the bleeding phenotype in this population and optimize clinical management." @default.
• W2049183222 created "2016-06-24" @default.
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• W2049183222 date "2015-04-01" @default.
• W2049183222 modified "2023-10-17" @default.
• W2049183222 title "A cross-sectional study of bleeding phenotype in haemophilia A carriers" @default.
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• W2049183222 doi "https://doi.org/10.1111/bjh.13423" @default.
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