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• W2049192110 abstract "Protease-activated receptors (PARs) comprise a family of G protein-coupled receptors with a unique proteolytic activation mechanism. PARs are activated by thrombin or other coagulation or inflammatory proteases formed at sites of tissue injury. PARs play a particularly important role in the pathogenesis of clinical disorders characterized by chronic inflammation or smoldering activation of the coagulation cascade. Individual PARs have been linked to the regulation of a broad range of cellular functions. Recent studies identify PAR family members in the vasculature (including within atherosclerotic lesions) and in the heart. Here, PAR-triggered responses contribute to vasoregulation and influence cardiac electrical and mechanical activity. PAR activation also is linked to structural remodeling of the vasculature and the myocardium. This review focuses on the cardiovascular actions of PARs that play a role in normal cardiovascular physiology and that are likely to contribute to cardiovascular diseases." @default.
• W2049192110 created "2016-06-24" @default.
• W2049192110 creator A5035111317 @default.
• W2049192110 date "2004-09-15" @default.
• W2049192110 modified "2023-10-14" @default.
• W2049192110 title "The Cardiovascular Actions of Protease-Activated Receptors" @default.
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• W2049192110 doi "https://doi.org/10.1124/mol.104.003103" @default.
• W2049192110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15371558" @default.
• W2049192110 hasPublicationYear "2004" @default.
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