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- W2049202301 abstract "This study was designed to clarify effects of ageing on human gastric mucosal prostaglandin (PG) contents. Forty examinees were divided into 5 age groups of 8 persons each, as follows: age under 40, age 40–49, age 50–59, age 60–69, and age over 70. PG contents in human gastric mucosa were measured by microcolumn high performance liquid chromatography (HPLC) with helium/cadmium laser induced fluorescence detection using biopsy samples obtained by endoscopy. The contents of 6-keto-PGF1α, PGF2α, PGE2, and PGD2 in the under 40 group were 638±39, 97±16, 468±68, 497±86 (pg/mg tissue), respectively. No significant differences in PG contents among groups aged under 70 were observed. In contrast, significantly low PG contents in the over 70 group were observed, i.e., the contents of 6-keto-PGF1α, PGF2α, PGE2, and PGD2 were 311±58, 36±8, 196±48, 171±40, respectively, and their contents were significantly lower than those in other age groups. In conclusion, gastric mucosal PG contents decrease significantly in over 70 years-old and this might be a contributing factor in the pathogenesis of gastric ulcers in elderly people." @default.
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- W2049202301 date "1992-08-01" @default.
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- W2049202301 title "Age-associated decreases in prostaglandin contents in human gastric mucosa" @default.
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- W2049202301 doi "https://doi.org/10.1016/s0006-291x(05)81568-2" @default.
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