FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2049202753> ?p ?o ?g. }

• W2049202753 endingPage "275" @default.
• W2049202753 startingPage "269" @default.
• W2049202753 abstract "The apical protease of the human intrinsic apoptotic pathway, caspase-9, is activated in a polymeric activation platform known as the apoptosome. The mechanism has been debated, and two contrasting hypotheses have been suggested. One of these postulates an allosteric activation of monomeric caspase-9; the other postulates a dimer-driven assembly at the surface of the apoptosome—the “induced proximity” model. We show that both Hofmeister salts and a reconstituted mini-apoptosome activate caspase-9 by a second-order process, compatible with a conserved dimer-driven process. Significantly, replacement of the recruitment domain of the apical caspase of the extrinsic apoptotic pathway, caspase-8, by that of caspase-9 allows activation of this hybrid caspase by the apoptosome. Consequently, apical caspases can be activated simply by directing their zymogens to the apoptosome, ruling out the requirement for allosteric activation and supporting an induced proximity dimerization model for apical caspase activation in vivo." @default.
• W2049202753 created "2016-06-24" @default.
• W2049202753 creator A5037589339 @default.
• W2049202753 creator A5076328766 @default.
• W2049202753 creator A5087530743 @default.
• W2049202753 creator A5089691375 @default.
• W2049202753 date "2006-04-01" @default.
• W2049202753 modified "2023-10-17" @default.
• W2049202753 title "The Apoptosome Activates Caspase-9 by Dimerization" @default.
• W2049202753 cites W1492587973 @default.
• W2049202753 cites W1506642042 @default.
• W2049202753 cites W1968505830 @default.
• W2049202753 cites W1973436922 @default.
• W2049202753 cites W1976141746 @default.
• W2049202753 cites W197615574 @default.
• W2049202753 cites W1976842123 @default.
• W2049202753 cites W1979444649 @default.
• W2049202753 cites W1980921389 @default.
• W2049202753 cites W1986514098 @default.
• W2049202753 cites W1995943393 @default.
• W2049202753 cites W2002329941 @default.
• W2049202753 cites W2008880656 @default.
• W2049202753 cites W2010243701 @default.
• W2049202753 cites W2014196693 @default.
• W2049202753 cites W2023158524 @default.
• W2049202753 cites W2024105041 @default.
• W2049202753 cites W2033260606 @default.
• W2049202753 cites W2056155809 @default.
• W2049202753 cites W2060670004 @default.
• W2049202753 cites W2062014088 @default.
• W2049202753 cites W2074152898 @default.
• W2049202753 cites W2074290479 @default.
• W2049202753 cites W2075352602 @default.
• W2049202753 cites W2083699890 @default.
• W2049202753 cites W2087128996 @default.
• W2049202753 cites W2087593127 @default.
• W2049202753 cites W2091267060 @default.
• W2049202753 cites W2110252008 @default.
• W2049202753 cites W2119586900 @default.
• W2049202753 cites W2119683782 @default.
• W2049202753 cites W2122028337 @default.
• W2049202753 cites W2134367544 @default.
• W2049202753 cites W2145006562 @default.
• W2049202753 cites W2148784517 @default.
• W2049202753 doi "https://doi.org/10.1016/j.molcel.2006.03.009" @default.
• W2049202753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16630894" @default.
• W2049202753 hasPublicationYear "2006" @default.
• W2049202753 type Work @default.
• W2049202753 sameAs 2049202753 @default.
• W2049202753 citedByCount "254" @default.
• W2049202753 countsByYear W20492027532012 @default.
• W2049202753 countsByYear W20492027532013 @default.
• W2049202753 countsByYear W20492027532014 @default.
• W2049202753 countsByYear W20492027532015 @default.
• W2049202753 countsByYear W20492027532016 @default.
• W2049202753 countsByYear W20492027532017 @default.
• W2049202753 countsByYear W20492027532018 @default.
• W2049202753 countsByYear W20492027532019 @default.
• W2049202753 countsByYear W20492027532020 @default.
• W2049202753 countsByYear W20492027532021 @default.
• W2049202753 countsByYear W20492027532022 @default.
• W2049202753 countsByYear W20492027532023 @default.
• W2049202753 crossrefType "journal-article" @default.
• W2049202753 hasAuthorship W2049202753A5037589339 @default.
• W2049202753 hasAuthorship W2049202753A5076328766 @default.
• W2049202753 hasAuthorship W2049202753A5087530743 @default.
• W2049202753 hasAuthorship W2049202753A5089691375 @default.
• W2049202753 hasBestOaLocation W20492027531 @default.
• W2049202753 hasConcept C12554922 @default.
• W2049202753 hasConcept C163421366 @default.
• W2049202753 hasConcept C166342909 @default.
• W2049202753 hasConcept C178790620 @default.
• W2049202753 hasConcept C181199279 @default.
• W2049202753 hasConcept C185592680 @default.
• W2049202753 hasConcept C190283241 @default.
• W2049202753 hasConcept C193349765 @default.
• W2049202753 hasConcept C2775998712 @default.
• W2049202753 hasConcept C2779546866 @default.
• W2049202753 hasConcept C31573885 @default.
• W2049202753 hasConcept C55493867 @default.
• W2049202753 hasConcept C86803240 @default.
• W2049202753 hasConcept C95444343 @default.
• W2049202753 hasConcept C98424977 @default.
• W2049202753 hasConceptScore W2049202753C12554922 @default.
• W2049202753 hasConceptScore W2049202753C163421366 @default.
• W2049202753 hasConceptScore W2049202753C166342909 @default.
• W2049202753 hasConceptScore W2049202753C178790620 @default.
• W2049202753 hasConceptScore W2049202753C181199279 @default.
• W2049202753 hasConceptScore W2049202753C185592680 @default.
• W2049202753 hasConceptScore W2049202753C190283241 @default.
• W2049202753 hasConceptScore W2049202753C193349765 @default.
• W2049202753 hasConceptScore W2049202753C2775998712 @default.
• W2049202753 hasConceptScore W2049202753C2779546866 @default.
• W2049202753 hasConceptScore W2049202753C31573885 @default.
• W2049202753 hasConceptScore W2049202753C55493867 @default.
• W2049202753 hasConceptScore W2049202753C86803240 @default.
• W2049202753 hasConceptScore W2049202753C95444343 @default.
• W2049202753 hasConceptScore W2049202753C98424977 @default.

• next